AOC1 Antibody

Code CSB-PA104599
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA104599(AOC1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA104599(AOC1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
AOC1
Alternative Names
ABP antibody; Abp1 antibody; ABP1_HUMAN antibody; Amiloride binding protein 1 (amine oxidase (copper containing)) antibody; Amiloride binding protein 1 antibody; Amiloride binding protein antibody; Amiloride sensitive amine oxidase antibody; Amiloride-binding protein antibody; Amiloride-sensitive amine oxidase [copper-containing] antibody; Amine oxidase copper domain containing protein 1 antibody; AOC1 antibody; DAO antibody; DAO1 antibody; Diamine oxidase antibody; Histaminase antibody; KAO antibody; Kidney amine oxidase antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human AOC1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:15-1:50
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
Gene References into Functions
  1. this study shows that single nucleotide polymorphism is associated with the severity of allergic rhinitis in a group of Mexican children PMID: 27255477
  2. The T allele of rs3787429 exhibited protective effect against CHF under the dominant and additive models , while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study PMID: 26989676
  3. HRH1-17 TT and HNMT-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP 4107 GG genotype was associated with nonallergic asthma among white children. PMID: 25909280
  4. This study findings suggest that DAO genotypes and allelic variants are associated with the risk for migraine in Caucasian Spanish people, especially in women. PMID: 25612138
  5. Serum diamine oxidase levels were influenced by the menstrual cycle. PMID: 23099198
  6. Low diamine oxidase activity is associated with gastrointestinal tract toxicities during chemotherapy with oral fluorouracil anti-cancer drugs in patients with gastric cancer.( PMID: 22433290
  7. Diamine oxidase (DAO) variants were not associated with the histamine intolerance (HIT) phenotype per se, only with DAO activity alone and the subgroup of HIT patients displaying a reduced DAO activity. PMID: 21488903
  8. Low serum diamine oxidase activity in inflammatory bowel disease. PMID: 21225906
  9. structure of human DAO refined to 2.1 A resolution in space group C222(1) with one molecule in the asymmetric unit is reported. PMID: 20124708
  10. The study of a non-synonymous single nucleotide polymorphisms(rs1049793) of diamine oxidase gene does not seem to be of use in assessing susceptibility to CD PMID: 19670078
  11. could be detected at the feto-maternal interface of human PMID: 11603849
  12. for the diamine oxidase gene differences in allele distribution were found in patients with food allergy and sprue compared to controls PMID: 12755416
  13. newly identified DAO gene polymorphisms PMID: 15928835
  14. Individuals carrying the 645Asp amino acid displayed lower serum diamine oxidase activity as compared with noncarriers (P<0.001) with a significant gene-dose effect (P<0.05). PMID: 17700358
  15. An association of the HNMT Thr105Ile polymorphism, but not of the ABP1 His645Asp polymorphism, with PD was observed. Patients with PD showed a higher frequency of homozygous HNMT genotypes PMID: 17985251
  16. Results examine the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), plasma D-lactate and diamine oxidase (DAO) in patients with inflammatory bowel disease. PMID: 19701972
  17. An aspartic acid residue, conserved in all diamine oxidases, is responsible for the diamine specificity by interacting with the second amino group of preferred diamine substrates. PMID: 19764817

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Subcellular Location
Secreted, extracellular space.
Protein Families
Copper/topaquinone oxidase family
Tissue Specificity
Placenta and kidney.
Database Links

HGNC: 80

OMIM: 104610

KEGG: hsa:26

STRING: 9606.ENSP00000354193

UniGene: Hs.647097

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