APBA3 Antibody

Code CSB-PA080020
Size US$100
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Product Details

Uniprot No.
Target Names
APBA3
Alternative Names
Adapter protein X11gamma antibody; amyloid beta (A4) precursor protein binding; family A; member 3 antibody; Amyloid beta A4 precursor protein-binding family A member 3 antibody; Amyloid beta precursor protein binding; family A; member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein antibody; APBA3 antibody; APBA3_HUMAN antibody; lin 10 antibody; MGC:15815 antibody; Mint 3 antibody; Mint-3 antibody; Neuron specific X11L2 protein antibody; Neuron-specific X11L2 protein antibody; Neuronal Munc18 1 interacting protein 3 antibody; Neuronal Munc18-1-interacting protein 3 antibody; phosphotyrosine binding/interacting domain (PTB) bearing protein antibody; X11 like 2 protein 2 antibody; X11gamma antibody; X11L2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human X11γ.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Gene References into Functions
  1. Results suggest that NECAB3, a novel Mint3-binding protein, activates HIF-1 to promote normoxic glycolysis and tumorigenicity by forming a ternary complex with Mint3 and FIH-1. PMID: 26948053
  2. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. PMID: 24867948
  3. Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production. PMID: 24742670
  4. Strict specificity for recruitment of the Mint3 adaptor by APP at the Golgi, a critical role for Tyr-682 (within the YENPTY motif) in Mint3 recruitment and export of APP from the Golgi, are demonstrated. PMID: 23965993
  5. These results indicate that all three amyloid beta protein precursor family members are capable of activating gene transcription via Mint3-Taz and Mint3-Yap. PMID: 21178287
  6. Two transcriptional coactivators, TAZ and YAP, functionally associate with amyloid precursor protein through Mint3 and form transcriptionally active triple protein complexes. PMID: 20016085
  7. Associated with etilogical mechanism of Alzheimer's disease. PMID: 11831025
  8. Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV PMID: 14990567
  9. We have examined the ability of Bcr to interact with other epithelial PDZ proteins and found specific binding to both the apical PDZK1 protein and the Golgi-localized Mint3 PMID: 15494376
  10. These data implicate Mint3 activity as a critical determinant of post-Golgi APP traffic. PMID: 17959829
  11. the interaction between the PTB domain of Mint3 and the acidic peptide signal of Furin regulates the specific localization of Furin in the trans-Golgi network PMID: 18544638
  12. Mint3 regulates the FIH-1-HIF-1 pathway, which controls ATP production in macrophages PMID: 19726677

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Subcellular Location
Cytoplasm, perinuclear region.
Tissue Specificity
Expressed in all tissues examined with lower levels in brain and testis.
Database Links

HGNC: 580

OMIM: 604262

KEGG: hsa:9546

STRING: 9606.ENSP00000315136

UniGene: Hs.25527

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