APBA3 Antibody

1. Results suggest that NECAB3, a novel Mint3-binding protein, activates HIF-1 to promote normoxic glycolysis and tumorigenicity by forming a ternary complex with Mint3 and FIH-1. PMID: 26948053
2. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. PMID: 24867948
3. Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production. PMID: 24742670
4. Strict specificity for recruitment of the Mint3 adaptor by APP at the Golgi, a critical role for Tyr-682 (within the YENPTY motif) in Mint3 recruitment and export of APP from the Golgi, are demonstrated. PMID: 23965993
5. These results indicate that all three amyloid beta protein precursor family members are capable of activating gene transcription via Mint3-Taz and Mint3-Yap. PMID: 21178287
6. Two transcriptional coactivators, TAZ and YAP, functionally associate with amyloid precursor protein through Mint3 and form transcriptionally active triple protein complexes. PMID: 20016085
7. Associated with etilogical mechanism of Alzheimer's disease. PMID: 11831025
8. Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV PMID: 14990567
9. We have examined the ability of Bcr to interact with other epithelial PDZ proteins and found specific binding to both the apical PDZK1 protein and the Golgi-localized Mint3 PMID: 15494376
10. These data implicate Mint3 activity as a critical determinant of post-Golgi APP traffic. PMID: 17959829
11. the interaction between the PTB domain of Mint3 and the acidic peptide signal of Furin regulates the specific localization of Furin in the trans-Golgi network PMID: 18544638
12. Mint3 regulates the FIH-1-HIF-1 pathway, which controls ATP production in macrophages PMID: 19726677

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HGNC: 580

OMIM: 604262

KEGG: hsa:9546

STRING: 9606.ENSP00000315136

UniGene: Hs.25527