ARHGAP10 Antibody

Datasheet

Code	CSB-PA002012LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002012LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA002012LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARHGAP10 Polyclonal antibody

Uniprot No.

A1A4S6

Target Names

ARHGAP10

Alternative Names

Arhgap10 antibody; Graf-related protein 2 antibody; GRAF2 antibody; GTPase regulator associated with focal adhesion kinase 2 antibody; PS GAP antibody; PSGAP antibody; RHG10_HUMAN antibody; Rho GTPase-activating protein 10 antibody; Rho-type GTPase-activating protein 10 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Rho GTPase-activating protein 10 protein (542-744AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ARHGAP10 Antibody (Product code: CSB-PA002012LA01HU) is Non-conjugated. For ARHGAP10 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA002012LB01HU	ARHGAP10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002012LC01HU	ARHGAP10 Antibody, FITC conjugated
Biotin	CSB-PA002012LD01HU	ARHGAP10 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.

Gene References into Functions

ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. PMID: 27010858
In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)). PMID: 20158304
PS-GAP is a novel regulator of caspase-activated PAK-2 PMID: 15471851

Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane.

Tissue Specificity

High levels of expression in heart and skeletal muscle.

Database Links

HGNC: 26099

OMIM: 609746

KEGG: hsa:79658

STRING: 9606.ENSP00000336923

UniGene: Hs.368631

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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