ARL6IP1 Antibody

Code CSB-PA614878LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA614878LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA614878LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA614878LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARL6IP1 Polyclonal antibody
Uniprot No.
Target Names
ARL6IP1
Alternative Names
ARL6IP1; ARL6IP; ARMER; KIAA0069; ADP-ribosylation factor-like protein 6-interacting protein 1; ARL-6-interacting protein 1; Aip-1; Apoptotic regulator in the membrane of the endoplasmic reticulum
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human ADP-ribosylation factor-like protein 6-interacting protein 1 protein (93-133AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARL6IP1 Antibody (Product code: CSB-PA614878LA01HU) is Non-conjugated. For ARL6IP1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA614878LB01HU ARL6IP1 Antibody, HRP conjugated ELISA
FITC CSB-PA614878LC01HU ARL6IP1 Antibody, FITC conjugated
Biotin CSB-PA614878LD01HU ARL6IP1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
Gene References into Functions
  1. ARL6ip1 is a three-spanning transmembrane protein with a conophylline binding pocket. PMID: 24076029
  2. Down-regulation of ARL6IP1 expression arrested CaSki cell cycling at the G0/G1 phase and mitigated CaSki cell migration, determined by wound healing assays. PMID: 20213509
  3. ARL6IP1 may play a key role in cisplatin-induced apoptosis in CaSki cervical cancer cells by regulating the expression of apoptosis-associated proteins. PMID: 20372863
  4. novel endoplasmic reticulum integral membrane protein which protects cells by inhibiting caspase-9 activity and reveal a possible role for ARMER in cell survival PMID: 12754298
Involvement in disease
Spastic paraplegia 61, autosomal recessive (SPG61)
Subcellular Location
Endomembrane system; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein Families
ARL6ip family
Tissue Specificity
Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart.
Database Links

HGNC: 697

OMIM: 607669

KEGG: hsa:23204

STRING: 9606.ENSP00000306788

UniGene: Hs.634882

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