ASB2 Antibody

1. Notch signaling can initiate Asb2 transcription and NF-kappa B activation in T cell acute lymphoblastic leukemia cells. PMID: 30116272
2. Using ASB2 conditional knockout mice. PMID: 26537633
3. Phosphorylation of serine 323 of ASB2 alpha by Erk kinases is critical for ASB2alpha-mediated degradation of FLNA. PMID: 24044920
4. data therefore reveal ubiquitin acceptor sites in FLNa and establish that ASB2alpha-mediated effects on cell spreading are due to loss of filamins. PMID: 24052262
5. Data show that neither endogenous nor exogenously expressed ASB2alpha induces degradation of JAK proteins in hematopoietic cells PMID: 22916308
6. These results suggest that ASB2beta but not ASB2alpha might be monoubiquitinated and that the ASB2beta UIM motif, but not its E3 Ub ligase activity, plays a pivotal role in this monoubiquitination. PMID: 22382022
7. A model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL degradation and HOX gene down-regulation. PMID: 22174154
8. ASB2alpha is a novel regulator of integrin-dependent adhesion of hematopoietic cells PMID: 21737450
9. By shifting monomeric E3 ligase complexes to dimeric forms through activation of Asb2 transcription, Notch could effectively control the turnover of a variety of substrates and it exerts diverse effects on cell proliferation and differentiation. PMID: 21119685
10. ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins A and B for degradation. PMID: 18799729

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HGNC: 16012

OMIM: 605759

KEGG: hsa:51676

STRING: 9606.ENSP00000451575

UniGene: Hs.510327