BCL7B Antibody

Code CSB-PA002628GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
BCL7B
Alternative Names
B cell CLL/lymphoma 7 protein family member B antibody; B cell CLL/lymphoma 7B antibody; B-cell CLL/lymphoma 7 protein family member B antibody; BCL 7B antibody; BCL7B antibody; BCL7B_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human BCL7B
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression.
Gene References into Functions
  1. We herewith propose that the BCL7B gene, located in the chromosomal region commonly deleted in Williams syndrome, could potentially have a role in this particular association. PMID: 27771473
  2. our data indicate that BCL7B/BCL-7 has some roles in maintaining the structure of nuclei and is involved in the modulation of multiple pathways, including Wnt and apoptosis. PMID: 25569233
  3. BCL7B gene deltion is associated with Williams-Beuren Syndrome leading to Burkitt Leukemia. PMID: 23018576
Involvement in disease
BCL7B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Protein Families
BCL7 family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 1005

OMIM: 605846

KEGG: hsa:9275

STRING: 9606.ENSP00000223368

UniGene: Hs.647051

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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