BEST2 Antibody

Datasheet

Code	CSB-PA080178
Size	US$100
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Image	Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using BEST2 Polyclonal Antibody. Western blot analysis of 1) Mouse Brain Tissue, 2) Rat Brain Tissue using BEST2 Polyclonal Antibody.
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Product Details
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Target Background

Product Details

Uniprot No.

Q8NFU1

Target Names

BEST2

Alternative Names

BEST2; VMD2L1; Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1

Raised in

Rabbit

Species Reactivity

Mouse,Rat

Immunogen

Synthetic Peptide

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Form

Liquid

Tested Applications

WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1000
IHC	1:200-500

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Gene References into Functions

BEST2 and BEST4 could be added to the lineage-specific genes of humans intestinal epithelial cells PMID: 24223998
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon PMID: 20407206
These data suggest that Best2 may play a functional role in the regulation of aqueous flow and drainage in humans. PMID: 20157619
identified three novel VMD2-related human genes demonstrating a high degree of conservation in their respective RFP-TM domains [VMD2L1, VMD2L2, VMD2L3] PMID: 12032738
Results provide evidence that the bestrophins are expressed in pancreatic duct cells and, more specifically, that hBest1 plays a role in the calcium activated chloride channels found in these cells. PMID: 19237432
we examine data obtained from tissue-type and animal models and discuss the current state of bestrophin research, what roles Best2 may play in ocular epithelia and electrophysiology, how perturbation of these functions may result in disease. [REVIEW] PMID: 19398034

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Bestrophin family

Tissue Specificity

Mainly confined to the retinal pigment epithelium and colon.

Database Links

HGNC: 17107

OMIM: 607335

KEGG: hsa:54831

STRING: 9606.ENSP00000042931

UniGene: Hs.435611

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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