C1QTNF5 Antibody

1. High myonectin expression is associated with Type 2 Diabetes. PMID: 29161407
2. In children adipocyte C1QTNF5 expression is already strongly related to the degree of obesity and is associated with obesity-related AT alterations, systemic CTRP5 serum levels as well as circulating markers of metabolic disease and is positively regulated by TNFalpha in vitro PMID: 28239164
3. Sequencing of C1QTNF5 revealed 28 unique variants although none showed a statistically significant association with dt-GA when compared with 1000G individuals. PMID: 27149696
4. Our results provide the first genetic and physiological evidence for CTRP5 as a negative regulator of glucose metabolism and insulin sensitivity. Inhibition of CTRP5 action may result in the alleviation of insulin resistance associated with obesity and diabetes. PMID: 27143553
5. Late-onset retinal degeneration, proven to have the p.Ser163Arg mutation in C1QTNF5, and asked whether retina-wide sub-RPE deposit was detectable and quantifiable. PMID: 25010528
6. C1QTNF5 monomers can multimerize into a bouquet-like octadecamer. PMID: 24531000
7. CTRP-5 might be a novel adipokine that circulates abundantly in human sera. PMID: 23430573
8. C1QTNF5 retinopathy is an autosomal dominant LORD resulting in a complex ocular phenotype involving the RPE and ciliary epithelium. SD-OCT findings revealed widespread photoreceptor loss and diffuse choroidal thinning. PMID: 23289492
9. cloning of the bicistronic transcript and characterization of the upstream ORF, MFRP PMID: 11263980
10. The crystal structure of the trimeric globular domain of human C1QTNF5 at 1.34A resolution reveals unique features of this novel C1q family member. PMID: 22892318
11. Late-onset retinal degeneration is a progressive degeneration, and anterior segment abnormalities present early. PMID: 22277927
12. pathogenic role of C1qtnf5 Ser163Arg mutation PMID: 22110650
13. A physiological function for C1QTNF5 (myonectin) in linking insulin resistance with quantitative changes in mtDNA. PMID: 22031510
14. This study revealed the presence of a functional promoter for the CTRP5 gene located 5' of its start site. PMID: 20554618
15. CTRP5 has a role in extracellular deposit formation in late-onset retinal degeneration PMID: 12944416
16. A single locus at 11q23 is implicated in a complex ocular phenotype involving RPE and CE, tissues of neuroectodermal origin. PMID: 16123441
17. In this family with a proven mutation in this gene, peripupillary iris atrophy and abnormally long anterior zonular insertions were present before retinal changes and visual loss. PMID: 16376663
18. L-ORMD is due to insufficient levels of secreted C1QTNF5, compromised RPE cell function resulting from ER retention of the mutant protein or both mechanisms. PMID: 16600989
19. C1QTNF5 has a role in late-onset retinal degeneration PMID: 17249553

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HGNC: 14344

OMIM: 605670

KEGG: hsa:114902

STRING: 9606.ENSP00000402389

UniGene: Hs.632102