CBR4 Antibody

Datasheet

Code	CSB-PA850803ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA850803ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA850803ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CBR4 Polyclonal antibody

Uniprot No.

Q8N4T8

Target Names

CBR4

Alternative Names

3 oxoacyl [acyl carrier protein] reductase antibody; 3-oxoacyl-[acyl-carrier-protein] reductase antibody; Carbonic reductase 4 antibody; Carbonyl reductase 4 antibody; Carbonyl reductase family member 4 antibody; CBR 4 antibody; Cbr4 antibody; CBR4_HUMAN antibody; FLJ14431 antibody; Quinone reductase CBR4 antibody; SDR45C1 antibody; Short chain dehydrogenase/reductase family 45C member 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Carbonyl reductase family member 4 protein (1-237AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).

Gene References into Functions

CBR4 is a mitochondrial NADPH-dependent reductase for o- and p-quinones. PMID: 19000905
Hs17beta-HSD8 and HsCBR4 show a strong genetic interaction in vivo in yeast, where, only if they are expressed together, they rescue the respiratory deficiency and restore the lipoic acid content of oar1Delta cells. PMID: 19571038

Subcellular Location

Mitochondrion matrix.

Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Tissue Specificity

Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues.

Database Links

HGNC: 25891

KEGG: hsa:84869

STRING: 9606.ENSP00000303525

UniGene: Hs.659311

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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