CCAR2 Antibody

1. Since its up-regulation in cancer patients is usually associated with poor prognosis and its depletion reduces cancer cell growth in vitro, CCAR2 was suggested to act as a tumor promoter. However, there is also evidence that CCAR2 functions as a tumor suppressor and therefore its role in cancer formation and progression is still unclear. Review. PMID: 29807573
2. CCAR2/DBC1 inhibits recombination by limiting the initiation and the extent of DNA end resection, thereby acting as an antagonist of CtIP. PMID: 27503537
3. conclude, these findings demonstrated that DBC1 was essential in tumorigenesis and proliferation. Moreover, it was identified as a potential therapeutic target for HCC. PMID: 29106957
4. Long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. PMID: 28973437
5. Data suggest that DBC1 has a dual function in regulating beta-catenin-PROX1 signaling axis: as a coactivator for both beta-catenin and PROX1. PMID: 26477307
6. These results establish an important role for CCAR2 in cancer cells proliferation and could shed new light on novel therapeutic strategies against cancer, devoid of detrimental side effects. PMID: 27809307
7. important role for CCAR2 in maintaining cell cycle progression and promoting squamous cell carcinoma (SCC) tumorigenesis. PMID: 27725203
8. Data show that the interaction between cell cycle and apoptosis regulator 2 (CCAR2) and heat shock protein 60 (Hsp60) increases in the presence of rotenone. PMID: 28254432
9. Results found transcriptional levels of DBC1,a negative regulator of HDAC3 significantly reduced in type 2 diabetes mellitus patients. PMID: 27904654
10. DBC1 protein could be a prognostic marker of shorter recurrence-free survival in hepatocellular carcinoma patients after hepatectomy and human hepatocarcinogenesis was a multistep process accompanied by a stepwise increase in high DBC1 expression from low-grade dysplastic nodules, through high-grade dysplastic nodules, to hepatocellular carcinoma. PMID: 27083241
11. Results suggest that DBC1 is integral to the maintenance of the circadian molecular clock. PMID: 26657080
12. loss of DBC1 expression plays a role in tumorigenesis and tumor progression in gallbladder carcinoma. PMID: 26617872
13. Proteosome-mediated degradation and poly-ubiquitination of AR were increased with the knock-down of DBC1. PMID: 26249023
14. These studies further extend and confirm the role of CCAR2 in the DNA damage response and DNA repair PMID: 26158765
15. The results suggest that the PP4-mediated dephosphorylation of DBC1 is necessary for efficient damage responses in cells. PMID: 26194823
16. These results indicate that the expression of DBC1 and BRCA1 are closely related with in the progression of ovarian carcinomas PMID: 25823848
17. the results indicated that DBC1 promotes anoikis resistance in gastric cancer cells by regulating NF-kappaB activity and may thus be a new therapeutic target for preventing potential metastasis PMID: 26035299
18. DBC1 modification by Small Ubiquitin-like Modifier 2/3 is crucial for p53 transactivation under genotoxic stress. PMID: 25406032
19. molecular mechanism underlying DBC1 function in PEA3-mediated transcription involves inhibition of SIRT1 interaction with PEA3 and of SIRT1-mediated deacetylation of PEA3 PMID: 25417701
20. DBC1 might promote adipose tissue inflammation and senescence in obese subjects PMID: 25682741
21. Although DBC1 gene expression was reduced in adipose tissue from obese subjects, it was negatively associated with ADIPOQ gene expression in VAT, suggesting that DBC1 might promote visceral adipose tissue dysfunction. PMID: 25648830
22. These results clearly indicate a novel mechanism in which CCAR2 may regulate the transcriptional activation function of LXRalpha due to its specific inhibition of SIRT1 and serve to regulate cellular proliferation. PMID: 25661920
23. We propose that DBC1 is part of the molecular machinery that regulates fat storage capacity in adipocytes and participates in the "turn-off" switch that limits adipocyte fat accumulation. PMID: 25053585
24. CK2 alpha is an independent prognostic indicator for gastric carcinoma patients and is involved in tumorigenesis by regulating the phosphorylation of DBC1. PMID: 24962073
25. The results link Chk2 and REGgamma to the mechanism underlying the DBC1-dependent SIRT1 inhibition. PMID: 25361978
26. cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 PMID: 24824780
27. These results suggest that DBC1 is over-expressed in colorectal cancer and that it might serve as a predictor for selecting patients at high risk of poor prognosis. PMID: 23299276
28. demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients PMID: 24019980
29. Results reveal novel mechanisms by which TFII-I and DBC1 can modulate cellular fate by affecting cell-cycle control as well as the homologous recombination pathway. PMID: 24231951
30. DBC1 as a novel regulator of gluconeogenesis. PMID: 24415752
31. DBC1 may be implicated in the regulation of cancer cell energy metabolism. [Review] PMID: 23841676
32. This study demonstrates that the acetylation status of P53 and the expression of SIRT1, DBC1, and AR could be new prognostic indicators for clear cell renal cell carcinoma PMID: 24018803
33. Protein acetylation serves as an endogenous regulatory mechanism for SIRT1-DBC1 binding. PMID: 23892437
34. MOF acetylation of DBC1 inhibits binding to SirT1 and serves as a mechanism that connects DNA damage signaling to SirT1 and cell fate determination. PMID: 24126058
35. Our findings integrate KSR1 into a network involving DBC1 and SIRT1, which results in the regulation of p53 acetylation and its transcriptional activity. PMID: 24129246
36. DBC1 is an important co-factor for the control of the IKK-beta-NF-kappaB signaling pathway that regulates anoikis. PMID: 23588592
37. DBC1 enhances cell survival against UV irradiation.Therefore, DBC1 plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. PMID: 23352644
38. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. PMID: 22735644
39. Data indicate that an increase in cAMP/PKA activity resulted in the dissociation of SIRT1 and DBC1 in an AMP-activated protein kinase (AMPK)-dependent manner. PMID: 22553202
40. data indicate that the DBIRD complex (consisting of DBC1 and ZNF326) acts at the interface between mRNP particles and RNAPII, integrating transcript elongation with the regulation of alternative splicing PMID: 22446626
41. Suggest that DBC1 may promote tumor progression, and DBC1 could be a prognostic biomarker in esophageal squamous cell carcinoma. PMID: 22127596
42. results implicate the principal role of DBC1 in regulating ERbeta-dependent gene expressions PMID: 20074560
43. HDAC3 is negatively regulated by the nuclear protein DBC1 PMID: 21030595
44. DBC1 may modulate the cellular functions of BRCA1 and have important implications in the understanding of carcinogenesis in breast tissue. PMID: 20160719
45. New role for DBC1 as an in vivo regulator of SIRT1 activity and liver steatosis, in which interaction with SIRT1 may serve as a new target for therapies aimed at nonalcoholic liver steatosis. PMID: 20071779
46. Expression of DBC1 and SIRT1 is a significant prognostic indicator for gastric carcinoma patients. PMID: 19509139
47. Results identify DBC1 as a novel cellular inhibitor of SUV39H1 activity, and suggest that DBC1 may be an important regulator of heterochromatin formation and genomic stability by disrupting the SUV39H1-SirT1 complex and inactivating both enzymes. PMID: 19218236
48. Caspase-dependent processing of DBC-1 may act as a feed-forward mechanism to promote apoptosis and possibly also tumor suppression. PMID: 15824730
49. biological function for DBC-1 in the modulation of ERalpha expression and hormone-independent breast cancer cell survival PMID: 17473282
50. DBC1 directly interacts with SIRT1 and inhibits SIRT1 activity in vitro and in vivo PMID: 18235501

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HGNC: 23360

OMIM: 607359

KEGG: hsa:57805

STRING: 9606.ENSP00000310670

UniGene: Hs.744848