CCNDBP1 Antibody

1. Data suggest MAID/CCNDBP1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); MAID does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis. PMID: 26002959
2. GCIP underexpression is associated with Osteosarcoma. PMID: 26107195
3. Data indicate that grap2 and cyclin D1 interacting protein (GCIP) and inhibitor of of DNA binding/differentiation 1 (Id1) are inversely expressed in non-small cell lung cancer (NSCLC) cell lines and specimens. PMID: 24970809
4. The first structure of a free-standing human dominant-negative helix-loop-helix protein (DIP1) was reported. DIP1 adopts a V-shaped conformation, with N-terminal and C-terminal five-helix bundles connected by the HLH region. PMID: 22453338
5. It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 20460530
6. In transgenic mice, GCIP functions as a transcriptional suppressor, regulates cyclin D1 expression, inhibits cell growth and colony formation in human HepG2 cells, suggesting GCIP plays a significant role in tumor initiation and development. PMID: 16501603
7. CT847 interacts with mammalian Grap2 cyclin D-interacting protein PMID: 17532760
8. P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 17621266
9. Data suggest that HHM/Maid regulates a subset of TGF-beta target genes including the Olig1-Smad synexpression group. PMID: 18923419
10. decreased expression of GCIP in vivo is present in human breast carcinoma. PMID: 18983464
11. Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator PMID: 19153449

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HGNC: 1587

OMIM: 607089

KEGG: hsa:23582

STRING: 9606.ENSP00000300213

UniGene: Hs.36794