CEP63 Antibody

Datasheet

Code	CSB-PA839376LA01HU
Size	US$166
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Image	Western blot All lanes: CEP63 antibody at 12µg/ml Lane 1: K562 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: NIH/3T3 whole cell lysate Lane 4: Raji whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 82, 64, 58, 56 kDa Observed band size: 64 kDa Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA839376LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CEP63 Polyclonal antibody

Uniprot No.

Q96MT8

Target Names

CEP63

Alternative Names

CEP63Centrosomal protein of 63 kDa antibody; Cep63 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Centrosomal protein of 63 kDa protein (1-495AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CEP63 Antibody (Product code: CSB-PA839376LA01HU) is Non-conjugated. For CEP63 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA839376LB01HU	CEP63 Antibody, HRP conjugated	ELISA
FITC	CSB-PA839376LC01HU	CEP63 Antibody, FITC conjugated
Biotin	CSB-PA839376LD01HU	CEP63 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.

Gene References into Functions

CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated. PMID: 26400686
centrosomal Cdk1 signals were strongly diminished in cells treated with Cep63 siRNA when sc-54 was used for Cdk1 labeling PMID: 25643699
both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. PMID: 23936128
Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
One new SNP (rs112926188) in CEP63O was reported. Analysis showed that rs112926188 allele substituting proline at the 61st residue position of CEP63 produced more flexibility in three-deimensional space. PMID: 22555018
Findings define Cep63 as a centrosomal recruitment factor for Cdk1 that is essential for mitotic entry, providing a physical link between the centrosome and the cell-cycle machinery. PMID: 21406398
CEP63 transcripts exhibited three different expression patterns, downregulation was found in about 50% of the cases analyzed and CEP63 gene transcription was associated with invasive tumors. PMID: 16410684

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Involvement in disease

Seckel syndrome 6 (SCKL6)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.

Protein Families

CEP63 family

Database Links

HGNC: 25815

OMIM: 614724

KEGG: hsa:80254

STRING: 9606.ENSP00000336524

UniGene: Hs.443301

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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