CHRNA2 Antibody

1. A crystal structure of a human neuronal CHRNA2 extracellular domain in pentameric assembly has been reported. PMID: 27493220
2. The rare variants in CHRNA2 were significantly associated with smoking status. PMID: 25450229
3. a heterozygous single-nucleotide substitution in CHRNA2 gene (c.1126 C>T; p. Arg376Trp) in subjects with benign familial infantile seizures PMID: 25847220
4. CHRNA2 mutations play a causative role in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). PMID: 25770198
5. Results show that D478E variation in nAChR alpha2 subunit increases the peak current responses of both alpha2beta2- and alpha2beta4-nAChRs; but the D478N variation in nAChR alpha2 subunit only increases the peak current responses of alpha2beta2-nAChRs PMID: 24950454
6. Level of cigarettes per day during adolescence and young adulthood is associated with CHRNB3A6, CHRNA5A3B4, and CHRNA2 PMID: 23943838
7. Results indicate that the CHRNA2 signal peptide mutation T22I modulates the function of both alpha2beta2- and alpha2beta4-nAChR and decreases sensitivities to nicotine and acetylcholine, and quite possibly increasing susceptibility to nicotine dependence PMID: 24467848
8. findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers PMID: 24253422
9. mutations of CHRNB2 and CHRNA2 genes may be rare in Chinese autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) population. PMID: 21287502
10. How mutations in the nAChRs can cause autosomal dominant nocturnal frontal lobe epilepsy PMID: 12121305
11. A new CHRNA2 mutation markedly increases the receptor sensitivity to acetylcholine, indicating that the nicotinic alpha 2 subunit alteration is the underlying cause. PMID: 16826524
12. data demonstrate the rarity of the identified CHRNA2 mutations in nocturnal frontal lobe epilepsy patients, supporting the recently reported hypothesis of a restricted role for this gene in the disease PMID: 18226955
13. The CHRNA2 rs2043063 SNP might be a risk factor for overweight/obesity in Koreans PMID: 18588430
14. Results suggest that neither CHRNA4 nor CHRNB2 plays a major role in Japanese methamphetamine-use disorder. PMID: 18991851
15. Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene PMID: 19383498

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HGNC: 1956

OMIM: 118502

KEGG: hsa:1135

STRING: 9606.ENSP00000385026

UniGene: Hs.57718