CIART Antibody

Datasheet

Code	CSB-PA850790LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA850790LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CIART Polyclonal antibody

Uniprot No.

Q8N365

Target Names

CIART

Alternative Names

CIART antibody; C1orf51Circadian-associated transcriptional repressor antibody; ChIP-derived repressor of network oscillator antibody; Chrono antibody; Computationally highlighted repressor of the network oscillator antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Circadian-associated transcriptional repressor protein (1-385AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CIART Antibody (Product code: CSB-PA850790LA01HU) is Non-conjugated. For CIART Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA850790LB01HU	CIART Antibody, HRP conjugated	ELISA
FITC	CSB-PA850790LC01HU	CIART Antibody, FITC conjugated
Biotin	CSB-PA850790LD01HU	CIART Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response.

Gene References into Functions

Study shows that:1- Chrono is a circadian clock gene whose transcription exhibits a robust circadian oscillation. 2- Is is a repressor of circadian transcriptional/translational feedback loops. 3- It may function to link epigenetic control mechanisms to stress responses. [review] PMID: 28010116

Subcellular Location

Nucleus. Nucleus, PML body.

Database Links

HGNC: 25200

OMIM: 615782

KEGG: hsa:148523

STRING: 9606.ENSP00000290363

UniGene: Hs.54680

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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