CIB2 Antibody

1. this study identifies CIB1 and CIB2 as host helper factors for HIV-1 replication that are required for optimal receptor-mediated viral entry PMID: 27489023
2. results suggest that GJB2 and CIB2 are common cause of hearing loss in different Pakistani ethnicities PMID: 29086887
3. High CIB2 expression is associated with ovarian Cancer. PMID: 28729416
4. Novel homozygous missense variant c.196C>T and compound heterozygous variants, c.[97C>T];[196C>T], were associated with nonsyndromic deafness. PMID: 26173970
5. We identified a novel variant (rs7164338) on chromosome 15q25.1 in the CIB2 associated with lower pulse wave velocity. PMID: 26378684
6. CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family PMID: 26426422
7. Data indicate that that CIB2 localizes to stereocilia and interacts with the USH proteins myosin VIIa and whirlin, suggesting CIB2 is a Ca2+-buffering protein essential for calcium homeostasis in the mechanosensory stereocilia of inner ear hair cells. PMID: 24022220
8. Consistent with molecular modeling predictions of calcium binding, CIB2 significantly decreased the ATP-induced calcium responses in heterologous cells, whereas mutations in deafness DFNB48 altered CIB2 effects on calcium responses PMID: 23023331
9. CIB2, as binding partners for the integrin alphaIIb subunit, which suggests that they are potentially involved in regulating integrin alphaIIb subunit activation. PMID: 22779914

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HGNC: 24579

OMIM: 605564

KEGG: hsa:10518

STRING: 9606.ENSP00000258930

UniGene: Hs.129867