CLEC16A Antibody

Code CSB-PA598332
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA598332(CLEC16A Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
CLEC16A
Alternative Names
CLEC16A antibody; KIAA0350Protein CLEC16A antibody; C-type lectin domain family 16 member A antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human CLEC16A
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.
Gene References into Functions
  1. Golgi-associated CLEC16A negatively regulates autophagy via modulation of mTOR activity. PMID: 28223137
  2. Study provides evidence that Clec16a plays a key role in the survival of Purkinje cells and in the degradative function or clearance of autolysosomes. PMID: 26987296
  3. A possible regulatory role for the multiple sclerosis-associated rs12927355 in CLEC16A. PMID: 26203907
  4. CLEC16A was found to be a susceptibility factor for SLE, with possible contribution to the development of the disease. PMID: 26121298
  5. Clec16a knockdown mice showed reduced number of B cells and elevated IgM levels compared with controls. PMID: 25891430
  6. identify CLEC16A as a pivotal gene in multiple sclerosis that serves as a direct regulator of the human leukocyte antigen class II pathway in antigen-presenting cells. PMID: 25823473
  7. data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS in men. PMID: 25447402
  8. This study demonstrated that the Polymorphism, Single Nucleotide of CLEC16A is associated with multiple sclerosis in Russia. PMID: 25903733
  9. The study suggested that a CLEC16A polymorphism may be protective against Vogt-Koyanagi-Harada syndrome syndrome in a Chinese Han population. PMID: 25576669
  10. Our results suggest that polymorphisms rs6498169 of CLEC16A gene confers susceptibility to AITDs. We therefore disclose for the first time the association of rs6498169 SNP with AITDs. PMID: 24646814
  11. Forty-eight SNPs, all located in CLEC16A, provided a statistically significant association with type 1 diabetes mellitus, with rs34306440 being most significantly associated. The mechanisim is likely through reduced expression of DEXI transcripts. PMID: 25008175
  12. Study demonstrates that a diabetogenic SNP in the CLEC16A locus correlates with islet CLEC16A expression, beta cell function, and glycemic control in human subjects. Clec16a controls beta cell function and prevents diabetes by controlling mitophagy. PMID: 24949970
  13. The data indicates a possible regulatory role for multiple sclerosis-associated non-coding CLEC16A SNPs and a common control mechanism for the expression of CLEC16A, SOCS1 and DEXI. PMID: 23151489
  14. Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women PMID: 23133532
  15. Genome-wide significant association was found for rs20541 and rs998592, thus establishing IL-13 and KIAA0350/CLEC16A as susceptibility loci for alopecia areata. IL-13 and KIAA0350/CLEC16A are also susceptibility loci for other autoimmune diseases. PMID: 22534877
  16. Fine mapping identified 26 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 and 11 SNPs across the SPIB locus with significant association to primary biliary cirrhosis. PMID: 22257840
  17. A significant association with multiple sclerosis is found for four single nucleotide polymorphisms within the CLEC16A gene, all located in the same linkage disequilibrium (LD) block. PMID: 20849399
  18. Data show independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex in multiple sclerosis susceptibility. PMID: 21653641
  19. Expression analysis revealed that rs12708716 genotype was significantly associated with the relative expression levels of two different CLEC16A transcripts in thymus (P=0.004) PMID: 21179112
  20. Results show that CLEC16A does not have a prominent function in susceptibility to anti-cyclic citrullinated peptide (CCP)-positive rheumatoid arthritis. PMID: 20220768
  21. Studies indicate that SNP in IL7RA, IL2RA, CD58 and CLEC16A genes has been consistently associated with MS. PMID: 20450971
  22. SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals PMID: 20036365
  23. A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis PMID: 19734133
  24. The initial chi-square test revealed that the Cright curved arrow T polymorphism of CLEC16A and the Aright curved arrow G polymorphism of SPTBN5 were significantly ssociated with ischemic stroke among individuals with metabolic syndrome. PMID: 20043139
  25. Studies indicate that five SNPs showed genome-wide significant association with MS: HLA-DRA, IL7R, IL2RA, CD58 and CLEC16A. PMID: 19834503
  26. results indicate that KIAA0350 might be involved in the pathogenesis of type 1 diabetes and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits PMID: 17632545
  27. Two alleles at 16p13 are independently associated with the risk of Addison's disease in the Norwegian population, suggesting this chromosomal region to harbor common autoimmunity gene(s), CLEC16A and CIITA being possible independent candidates. PMID: 18593762
  28. There is evidence of a genome-wide significant association between KIAA0350 and risk of multiple sclerosis in Australians. PMID: 18650830
  29. Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Italy. PMID: 18946483
  30. CLEC16A is a multiple sclerosis susceptibility gene. PMID: 18987646
  31. The intron polymorphism rs725613 in the KIAA0350 gene is associated with susceptibility to type 1 diabetes in the Chinese population. PMID: 19178520
  32. Autoimmune disease association signals in KIAA0350 are not involved in celiac disease susceptibility PMID: 19317741
  33. a CLEC16A/KIAA0350 polymorphism may have a role in NOD2/CARD15(-) Crohn's disease patients PMID: 19337309

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Involvement in disease
Diabetes mellitus, insulin-dependent (IDDM)
Subcellular Location
Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
Protein Families
CLEC16A/gop-1 family
Tissue Specificity
Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells.
Database Links

HGNC: 29013

OMIM: 222100

KEGG: hsa:23274

STRING: 9606.ENSP00000387122

UniGene: Hs.35490

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