CNTNAP1 Antibody

Datasheet

Code	CSB-PA005692ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005692ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human glioma using CSB-PA005692ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CNTNAP1 Polyclonal antibody

Uniprot No.

P78357

Target Names

CNTNAP1

Alternative Names

Caspr antibody; Caspr1 antibody; CNTNAP antibody; Cntnap1 antibody; CNTP1_HUMAN antibody; Contactin associated protein 1 antibody; Contactin-associated protein 1 antibody; MHDNIV antibody; NCP1 antibody; Neurexin 4 antibody; Neurexin IV antibody; Neurexin-4 antibody; Nrxn4 antibody; p190 antibody; Paranodin antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Contactin-associated protein 1 protein (20-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.

Gene References into Functions

E. coli exploits Caspr1 as a host receptor for penetration of the blood-brain barrier, resulting in meningitis PMID: 29895952
In two brothers with severe congenital hypotonia and foot deformities, we identified compound heterozygous variants in CNTNAP1, reporting the first causative missense variant, p.(Cys323Arg). Motor nerve conductions were markedly decreased. PMID: 27782105
CNTNAP1 mutations were found to induce characteristic ultrastructural lesions of the paranodal region. PMID: 27818385
report a consanguineous Arab family from Qatar with three children having an early lethal form of arthrogryposis multiplex congenita and a novel frameshift mutation in CNTNAP1 PMID: 28254648
Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects PMID: 24319099

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Involvement in disease

Lethal congenital contracture syndrome 7 (LCCS7)

Subcellular Location

Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction.

Protein Families

Neurexin family

Tissue Specificity

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

Database Links

HGNC: 8011

OMIM: 602346

KEGG: hsa:8506

STRING: 9606.ENSP00000264638

UniGene: Hs.408730

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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