COG4 Antibody

Code CSB-PA881003ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA881003ESR1HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA881003ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) COG4 Polyclonal antibody
Uniprot No.
Target Names
COG4
Alternative Names
COG4Conserved oligomeric Golgi complex subunit 4 antibody; COG complex subunit 4 antibody; Component of oligomeric Golgi complex 4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Conserved oligomeric Golgi complex subunit 4 protein (506-785AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
Gene References into Functions
  1. A novel R729W missense mutation in COG4 was associated with the congenital disorder of glycosylation type II. PMID: 19494034
  2. The 1.9 A crystal structure of a Cog4 C-terminal fragment, was determined. Arg 729 is found to occupy a key position at the center of a salt bridge network, thereby stabilizing Cog4's small C-terminal domain. PMID: 19651599
Involvement in disease
Congenital disorder of glycosylation 2J (CDG2J)
Subcellular Location
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
COG4 family
Database Links

HGNC: 18620

OMIM: 606976

KEGG: hsa:25839

STRING: 9606.ENSP00000315775

UniGene: Hs.208680

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