CRIM1 Antibody

1. CRIM1 regulates the expression of several epithelial-mesenchymal transition (EMT) related factors and appears to play a role in suppressing migration and invasion through control of EMT. PMID: 29607933
2. these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature. PMID: 27803996
3. These observations provide evidence for the first time that CRIM1 plays a role in cancer cells by enhancing the migration and adhesion and increasing the expression of N-CAD and E-CAD. PMID: 26653968
4. CRIM1 is the causative gene for Colobomatous macrophthalmia with microcornea syndrome and is important for eye development. PMID: 25561690
5. Knock down of CRIM1 had no effect on VEGF-induced proliferation or migration of umbilical vein endothelial cells (HUVECs), indicating that basal CRIM1 is not involved in the proliferation or migration of endothelial cells. PMID: 25956066
6. Data suggest that CRIM1 plays role in cancer progression/metastasis, epithelial-mesenchymal transition, and neoplastic angiogenesis. [REVIEW] PMID: 25088037
7. BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF. PMID: 24617547
8. CRIM1 is an early response gene in the presence of both angiogenic stimulation (VEGF) and environmental (extracellular matrix) factors, and Erk and FAK might be involved in the upregulation of CRIM1 mRNA expression in vascular endothelial cells. PMID: 25086356
9. Study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance. PMID: 21036735
10. CRIM1 has a role in capillary formation and maintenance during angiogenesis PMID: 12464430
11. CRIM1 modulates BMP activity by affecting its processing and delivery to the cell surface PMID: 12805376

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HGNC: 2359

OMIM: 606189

KEGG: hsa:51232

STRING: 9606.ENSP00000280527

UniGene: Hs.699247