CSMD1 Antibody

1. we studied n=3437 individuals and found evidence that a variant in CSMD1 is associated with cognitive function. PMID: 27890662
2. Low expression of CSMD1 is associated with enhanced proliferation, migration and invasion. PMID: 28534981
3. Study provide experimental evidence for the role of CSMD1 as a tumor suppressor in vitro and in vivo in the progression of breast cancer. Results revealed that expression of CSMD1 significantly reduced cell motility and migration, adhesion and invasion, as well as the tumorigenic and signaling potential of human breast cancer cells. PMID: 27764775
4. rs10503253 is likely a common schizophrenia risk variant in multiple ethnic groups PMID: 28344127
5. Data show that micrRNA miR-10b is overexpressed in hepatocellular carcinoma (HCC) tissues and miR-10b mimics promoted HCC cell viability and invasion via targeting CUB and Sushi multiple domains 1 (CSMD1) expression. PMID: 27756250
6. findings do not support an association between CSMD1 rs10503253 and Schizophrenia in a Han Chinese population. PMID: 27377754
7. CSMD1 gene is a target for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma. PMID: 27636103
8. Allele-wise association analysis detected three SNPs, including rs2623659 in the CUB and Sushi multiple domains-1 (CSMD1) gene, associated with severity of illness at end point. The severity of illness at end point was associated with treatment response, but not with the severity of illness at baseline. Three SNPs, including rs2294424 in the C6orf105 gene, were associated with social outcomes. PMID: 26674612
9. This study failed to observe any association between rs12861349 and parkinson disear in iran population. PMID: 26732583
10. Loss of heterozygosity at D8S262 and down-regulation of CSMD1 expression may be early events in hepatocarcinogenesis. PMID: 26076954
11. In the first published genome-wide association study of postburn hypertrophic scarring (HTS), we report that a common intronic variant in the CSMD1 gene is associated with reduced severity of postburn HTS. PMID: 26366535
12. A SNP within CSMD1 associated with variation in the potential osteoarthritis biomarker uCTX-II levels with borderline genome-wide significance. PMID: 25057126
13. The associations of rs2616984 in CSMD1 gene, putative associations of rs3131296 in NOTCH4 gene, and associations of rs2229741 of NRIP1 gene with Alzheimer's disease have been found in a Russian population. PMID: 25845235
14. Results underline the relevance of the risk "A" allele to neurocognitive functioning and suggest that its detrimental effects on cognition, may be part of the mechanism by which the CSMD1 mediates risk for schizophrenia PMID: 24630139
15. CSMD1 and CSMD2 expressions were associated with overall survival PMID: 24408017
16. role of CSMD1 and SYNE1 in the etiology of bipolar disorder PMID: 24387768
17. Single nucleotide polymorphism rs10503253 within the CSMD1 gene is associated with cognition disorder in schizophrenia. PMID: 23839771
18. CSMD1 inhibits complement by promoting factor I-mediated C4b/C3b degradation and inhibition of membrane attack complex assembly. PMID: 23964079
19. results confirm the role of CSDM1 as a tumor suppressor gene in melanoma cells; study also found that CSMD1 can interact with Smad3, activate Smad1, Smad2, and Smad3, and increase the expression of Smad4 PMID: 22538441
20. TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking and alcohol intake affect risk of psoriasis. PMID: 23541940
21. CSMD1 alterations can correlate with earlier clinical presentation in colorectal tumors, thus further implicating CSMD1 as a tumor suppressor gene. PMID: 23505554
22. CSMD1 schizophrenia risk 'A' allele at rs10503253 is associated with impaired cognition and memory function, but not attentinal control. PMID: 23320435
23. data demonstrate a significant role of complement control-related genes in the etiology of schizophrenia. PMID: 21439553
24. Reduction of CSMD1 expression significantly associated with high tumour grade and decreased overall survival in invasive ductal breast carcinoma PMID: 19669408
25. Consistent genetic factors for ATP2B1, CSK, ARSG and CSMD1 were present, which have been shown to be associated with high blood pressure and hypertension in two Korean cohorts. PMID: 19960030
26. Simple inactivation of CSMD1 may not explain the deletions observed in oropharyngeal squamous cell carcinoma and may call into question the role of this gene in head and neck carcinogenesis. PMID: 12696061
27. CSMD1 mutations may play a role in the development of colorectal cancer. PMID: 18614856
28. Characterization of CSMD1 in a large set of primary lung, head and neck, breast, and skin cancer tissues is reported. PMID: 19276661
29. CSMD1 protein blocks activation of the classical complement pathway PMID: 16547280
30. BAC microarray-CGH detects homozygous deletion of CSMD1 in human bladder cancer specimens PMID: 16203795
31. The region around CSMD1 has the highest sequence diversity between humans and the highest sequence divergance between humans and chimps in the genome. PMID: 16421571
32. CSMD1 is located within fragile site FRA8B. PMID: 16221525
33. CSMD1 expression is aberrant in most SCC cell lines. Reduced expression is associated with methylation of a specific region of the promoter. Other defects include loss of specific exons during splicing and activation of cryptic promoters. PMID: 16153303
34. CSMD1 is a member of a suite of genes whose downregulation is predictive of prostate cancer relapse PMID: 12874026
35. CSMD1 expression is markedly decreased in high stage prostatic adenocarcinomas PMID: 15138198
36. CSMD1 protein domain structure and the sequence of the cytoplasmic tail are highly conserved between mammals and fish PMID: 12906867
37. Previously reported apparent homozygous deletions wholly contained within CSMD1 introns are a PCR artifact caused by SNPs within the primer sequences. The allele remaining after LOH can't be amplified by these primers. PMID: 14506705

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HGNC: 14026

OMIM: 608397

KEGG: hsa:64478

STRING: 9606.ENSP00000441462

UniGene: Hs.571466