CSNK1G2 Antibody

Code CSB-PA007366
Size US$100
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  • Western Blot analysis of HeLa cells using Casein Kinase Iγ2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CSNK1G2
Alternative Names
Casein kinase 1; gamma 2 antibody; Casein kinase I isoform gamma 2 antibody; Casein kinase I isoform gamma-2 antibody; CK1g2 antibody; CKI gamma 2 antibody; CKI-gamma 2 antibody; CSNK1G 2 antibody; Csnk1g2 antibody; KC1G2_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the N-terminal region of Human Casein Kinase Iγ2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Gene References into Functions
  1. MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia PMID: 28885613
  2. MTA1s interacts with CKI-gamma2, which can phosphorylate MTA1s in an antiestrogen-dependent manner.Estrogen stimulates CKI-gamma2. CKI-gamma2 phosphorylates and modulates the functions of MTA1s. PMID: 15077195
  3. Data indicate that SNPs rs740423, rs2277737, rs1059684 of CSNK1G2 gene may contribute to familial febrile convulsions in children. PMID: 15300631
  4. Ligand-dependent ubiquitination of Smad3 is regulated by CK1g2, an inhibitor of TGF-beta signaling. PMID: 18794808
  5. These results indicate that CKIgamma2 hyperphosphorylates the serine-repeat motif of CERT, thereby inactivating CERT and down-regulating the synthesis of sphingomyelin. PMID: 19005213

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Subcellular Location
Cytoplasm, cell cortex. Cytoplasm.
Protein Families
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Tissue Specificity
Testis.
Database Links

HGNC: 2455

OMIM: 602214

KEGG: hsa:1455

STRING: 9606.ENSP00000255641

UniGene: Hs.651905

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