DAND5 Antibody

Datasheet

Code	CSB-PA850835LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA850835LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA850835LA01HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DAND5 Polyclonal antibody

Uniprot No.

Q8N907

Target Names

DAND5

Alternative Names

BMP antagonist 3 antibody; CER2 antibody; cerberus 2 antibody; Cerberus like 2 antibody; Cerberus-like protein 2 antibody; Cerl-2 antibody; CERL2 antibody; CKTSF1B3 antibody; COCO antibody; CRL2 antibody; Cysteine knot superfamily 1 antibody; Cysteine knot superfamily 1 BMP antagonist 3 antibody; DAN domain family member 5 antibody; Dand5 antibody; DAND5_HUMAN antibody; DANTE antibody; GREM3 antibody; Gremlin-3 antibody; MGC126849 antibody; SP1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DAN domain family member 5 protein (23-189AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DAND5 Antibody (Product code: CSB-PA850835LA01HU) is Non-conjugated. For DAND5 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA850835LB01HU	DAND5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA850835LC01HU	DAND5 Antibody, FITC conjugated
Biotin	CSB-PA850835LD01HU	DAND5 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation.

Gene References into Functions

High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer. PMID: 26908452
In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy PMID: 28738792
A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces dormant breast cancer cells to undergo reactivation in the lung. PMID: 22901808

Subcellular Location

Secreted.

Protein Families

DAN family

Database Links

HGNC: 26780

OMIM: 609068

KEGG: hsa:199699

STRING: 9606.ENSP00000323155

UniGene: Hs.331981

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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