DAND5 Antibody

Code CSB-PA850835LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA850835LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA850835LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DAND5 Polyclonal antibody
Uniprot No.
Target Names
DAND5
Alternative Names
BMP antagonist 3 antibody; CER2 antibody; cerberus 2 antibody; Cerberus like 2 antibody; Cerberus-like protein 2 antibody; Cerl-2 antibody; CERL2 antibody; CKTSF1B3 antibody; COCO antibody; CRL2 antibody; Cysteine knot superfamily 1 antibody; Cysteine knot superfamily 1 BMP antagonist 3 antibody; DAN domain family member 5 antibody; Dand5 antibody; DAND5_HUMAN antibody; DANTE antibody; GREM3 antibody; Gremlin-3 antibody; MGC126849 antibody; SP1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DAN domain family member 5 protein (23-189AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DAND5 Antibody (Product code: CSB-PA850835LA01HU) is Non-conjugated. For DAND5 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA850835LB01HU DAND5 Antibody, HRP conjugated ELISA
FITC CSB-PA850835LC01HU DAND5 Antibody, FITC conjugated
Biotin CSB-PA850835LD01HU DAND5 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation.
Gene References into Functions
  1. High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer. PMID: 26908452
  2. In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy PMID: 28738792
  3. A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces dormant breast cancer cells to undergo reactivation in the lung. PMID: 22901808
Subcellular Location
Secreted.
Protein Families
DAN family
Database Links

HGNC: 26780

OMIM: 609068

KEGG: hsa:199699

STRING: 9606.ENSP00000323155

UniGene: Hs.331981

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