DAZ2 Antibody

Code CSB-PA623785ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623785ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA623785ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DAZ2 Polyclonal antibody
Uniprot No.
Target Names
DAZ2
Alternative Names
DAZ2 antibody; DAZ2_HUMAN antibody; DAZ3 antibody; Deleted in azoospermia 2 antibody; Deleted in azoospermia protein 2 antibody; Deleted in azoospermia protein 3 antibody; MGC126442 antibody; pDP1678 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Deleted in azoospermia protein 2 protein (1-200AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
Gene References into Functions
  1. study reported a new type of AZFc deletion (gr/gr-DAZ2-DAZ4-CDY1b) and hypothesis that this new deletion is the result of 2 successive events favored by the unstable structure of AZFc region; also demonstrated that this deletion constitutes a relative high-risk factor for male infertility in Tunisian population PMID: 27457284
  2. There appears to be an asociation of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. PMID: 23512232
  3. Deletion of DAZ2 and DAZ4 gene copies is associated with male infertility. PMID: 24878370
  4. DAZ gene copy number in severely idiopathic infertile men. Gene deletion of two copies of DAZ (DAZI and 2) was the cause of spermatogenic damage. PMID: 11883873
Involvement in disease
Spermatogenic failure Y-linked 2 (SPGFY2)
Subcellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
Protein Families
RRM DAZ family
Tissue Specificity
Testis specific.
Database Links

HGNC: 15964

OMIM: 400026

KEGG: hsa:57055

STRING: 9606.ENSP00000371870

UniGene: Hs.592257

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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