Name: DENND1A Antibody
Brand: CUSABIO
SKU: CSB-PA823472LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DENND1A Polyclonal antibody

Uniprot No.

Q8TEH3

Target Names

DENND1A

Alternative Names

Connecdenn 1 antibody; Connecdenn antibody; DEN1A_HUMAN antibody; DENN domain-containing protein 1A antibody; DENN/MADD domain containing 1A antibody; dennd1a antibody; FAM31A antibody; FLJ21129 antibody; FLJ38464 antibody; KIAA1608 antibody; OTTHUMP00000022090 antibody; Protein FAM31A antibody; RP11 230L22.3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DENN domain-containing protein 1A protein (1-559AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DENND1A Antibody (Product code: CSB-PA823472LA01HU) is Non-conjugated. For DENND1A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA823472LB01HU	DENND1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA823472LC01HU	DENND1A Antibody, FITC conjugated
Biotin	CSB-PA823472LD01HU	DENND1A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P.

Gene References into Functions

The association of DENND1A rs10818854 and rs10986105 variants with PCOS in Tunisian but not Bahraini women confirms the dependence of this association on the ethnic/racial origin of study subjects. PMID: 29325736
Genome-wide association studies have identified DENND1A as a candidate gene for polycystic ovary syndrome (PCOS). PCOS theca cells are shown to overexpress DENND1A splice variant 2 (V2), but not V1. Also, the genetic variation 330 bp upstream of exon 20A is not associated with VE variant expression. PMID: 27297658
DENND1A gene variant is likely to have influence on PCOS risk. PMID: 27488699
This meta-analysis suggested that rs2479106 and rs10818854 polymorphisms in the DENND1A gene were associated with increased risk of polycystic ovary syndrome PMID: 26757598
The guanine nucleotide exchange factor activity of connecdenn 1 and 2 are autoinhibited, and this is regulated by Akt activation downstream of insulin stimulation. PMID: 26055712
We demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women. PMID: 25626177
sequence analysis of the DENND1A gene of patients with PCOS did not identify alterations that alone could be responsible for the PCOS pathogenesis PMID: 24086769
DENND1A, plays a key role in the hyperandrogenemia associated with polycystic ovary syndrome. PMID: 24706793
THADA and DENND1A, carry risk alleles that are associated with endocrine and metabolic disturbances in PCOS patients of Han Chinese descent. PMID: 23208300
Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma. PMID: 22902918
The rs2479106 G allele was associated with decreased PCOS susceptibility PMID: 22504079
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. PMID: 22547425
At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations. PMID: 22180642

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Involvement in disease

Genetic variants in DENND1A may play a role in susceptibility to polycystic ovary syndrome (PCOS), the most common endocrine disease among premenopausal women. PCOS is a complex disorder characterized by infertility, hirsutism, obesity, various menstrual disturbances, and enlarged ovaries studded with atretic follicles.

Subcellular Location

Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane.

Database Links

HGNC: 29324

OMIM: 613633

KEGG: hsa:57706

STRING: 9606.ENSP00000362727

UniGene: Hs.744995

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Code	CSB-PA823472LA01HU
Size	US$166
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DENND1A Antibody

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Target Background