EHD3 Antibody

1. Data provide evidence that EHD3 might undergo its tumor suppressor functions at least in part through promoting the sorting of activated EGFR to the lysosomal degradative compartment and spatio-temporal regulation of EGFR signaling via ERK and AKT. PMID: 27811356
2. the residues Ala-519/Asp-520 of EHD1 and Asn-519/Glu-520 of EHD3 as defining the selectivity of these two paralogs for NPF-containing binding partners PMID: 27189942
3. The EHD3 gene may be associated with the endophenotype of cognitive function in major depressive disorder patients. PMID: 24997812
4. 3 SNPs present in the EHD3 gene, of which rs619002 and rs644926 were exclusively associated with female major depressive disorder PMID: 24607927
5. demonstrate Ehd3 growth inhibitory functions in glioma cells in vivo. We suggest that Ehd3 functions as a tumor suppressor gene and loss of its expression is a very common event in gliomas PMID: 24306026
6. The combined effect of the EHD3 and FREM3 genes may play an important role in developing major depressive disorder. PMID: 22337703
7. EHD3 is a previously unrecognized component of the cardiac remodeling pathway in heart failure. PMID: 22406195
8. presented herein promote a coordinated role for EHD proteins and Rab11-FIP2 in mediating endocytic recycling and provide evidence for the function of EHD3 in early endosome to endocytic recycling compartment transport PMID: 16251358
9. Our findings support a role for EHD3 in regulating endosome-to-Golgi transport, and as a consequence, lysosomal biosynthetic, but not secretory, transport pathways are also affected PMID: 19139087

Show More

Hide All

HGNC: 3244

OMIM: 605891

KEGG: hsa:30845

STRING: 9606.ENSP00000327116

UniGene: Hs.368808