EIF4EBP3 Antibody

Datasheet

Code	CSB-PA007565HA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA007565HA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA007565HA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EIF4EBP3 Polyclonal antibody

Uniprot No.

O60516

Target Names

EIF4EBP3

Alternative Names

EIF4EBP3Eukaryotic translation initiation factor 4E-binding protein 3 antibody; 4E-BP3 antibody; eIF4E-binding protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The EIF4EBP3 Antibody (Product code: CSB-PA007565HA01HU) is Non-conjugated. For EIF4EBP3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA007565HB01HU	EIF4EBP3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007565HC01HU	EIF4EBP3 Antibody, FITC conjugated
Biotin	CSB-PA007565HD01HU	EIF4EBP3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.

Gene References into Functions

Role of the eIF4EBP3 gene in miR-22-3p-mediated cervical squamous carcinoma cell growth PMID: 29333098
The data reveal that 4E-BP3 expression is controlled by the transcription factor TFE3 through a cis-regulatory element in the EIF4EBP3 gene promoter. PMID: 27319316
4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2 PMID: 22684010
potential prognostic factor for survival in patients with lung adenocarcinoma PMID: 20621385
4E-BP3 is associated with eIF4E in the cell nucleus and cytoplasm PMID: 12482586
PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin PMID: 14507920
there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK PMID: 14557257

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Protein Families

EIF4E-binding protein family

Tissue Specificity

Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.

Database Links

HGNC: 3290

OMIM: 603483

KEGG: hsa:8637

STRING: 9606.ENSP00000308472

UniGene: Hs.594084

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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