FBXL5 Antibody

1. Transcriptomic analysis shows downregulation of FBXL5 expression in HSCs of patients with myelodysplastic syndrome. PMID: 28714470
2. regulatory circuit involving FBXL5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth PMID: 28768766
3. analysis of the redox sensing mechanism by which FBXL5 can serve as an iron metabolism regulator within mammalian cells PMID: 28131773
4. FBXL5 regulates cortactin through induction of its ubiquitylation, and FBXL5 similarly regulates Snail1. PMID: 25832584
5. FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1alpha. PMID: 25956243
6. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism PMID: 24778179
7. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis PMID: 23135277
8. Data indicate that F-box and leucine-rich repeat protein 5 (FBXL5)-Hr (hemerythrin-like domain) undergoes substantive structural changes when iron becomes limiting, accounting for its switch-like behavior. PMID: 22648410
9. Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor. PMID: 22253436
10. iron homeostasis is regulated by a proteolytic pathway that couples IRP2 degradation to intracellular iron levels through the stability and activity of FBXL5 PMID: 19762596
11. observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 regulation, and cellular responses to maintain mammalian iron homeostasis PMID: 19762597
12. Our findings provide a potential mechanism by which p150(Glued) protein function is regulated by SCFs. PMID: 17532294

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HGNC: 13602

OMIM: 605655

KEGG: hsa:26234

STRING: 9606.ENSP00000344866

UniGene: Hs.643433