FCHSD2 Antibody

Datasheet

Code	CSB-PA008549LA01HU
Size	US$166
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Image	Western blot All lanes: FCHSD2 antibody at 12µg/ml Lane 1: U251 whole cell lysate Lane 2: A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 85, 78, 59 kDa Observed band size: 85 kDa Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008549LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA008549LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FCHSD2 Polyclonal antibody

Uniprot No.

O94868

Target Names

FCHSD2

Alternative Names

FCHSD2 antibody; KIAA0769 antibody; SH3MD3F-BAR and double SH3 domains protein 2 antibody; Carom antibody; Protein nervous wreck 1 antibody; NWK1 antibody; SH3 multiple domains protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FCHSD2 Antibody (Product code: CSB-PA008549LA01HU) is Non-conjugated. For FCHSD2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA008549LB01HU	FCHSD2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008549LC01HU	FCHSD2 Antibody, FITC conjugated
Biotin	CSB-PA008549LD01HU	FCHSD2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.

Gene References into Functions

Loss of FCHSD2 activity in nonsmall cell lung cancer (NSCLC) cells leads to increased cell-surface expression and altered signaling downstream of EGFR, resulting in enhanced cell proliferation and migration. PMID: 30249660
Established 3 models of Carom-receptor complexes and their intracellular trafficking based on protein interaction and subcellular localization. Carom may mediate receptor endocytosis and transport endocytic receptors to the cytoplasm for receptor signaling and lysosome/proteasome degradation. Review. PMID: 28199211
A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
our study, for the first time, demonstrates FCHSD2 as a predictor of outcome for Acute myeloid leukemia patients PMID: 22902056

Subcellular Location

Cytoplasm. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium.

Tissue Specificity

Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.

Database Links

HGNC: 29114

OMIM: 617556

KEGG: hsa:9873

STRING: 9606.ENSP00000386722

UniGene: Hs.744959

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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