GCNT2 Antibody

1. miR-199a/b-5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT PMID: 28542779
2. This study reports a novel insertion/deletion mutation at the GCNT2 locus that is responsible for congenital cataracts in a large consanguineous family. PMID: 27936067
3. GCNT2 expression is closely associated with invasive potential of prostate cancer. PMID: 26678556
4. Hypomethylation of the GCNT2 variant 2 reflected lymph node metastasis of colorectal cancer in the tumor and normal tissues. PMID: 25750292
5. An Alu repeat-mediated genomic GCNT2 deletion underlies congenital cataracts and adult i blood group PMID: 21761136
6. Results show involvement of GCNT2 in EMT and TGF-beta signaling, and further glycosylation modification of E-cadherin by GCNT2, are the underlying integrative mechanisms for breast cancer metastasis. PMID: 21750175
7. In the family with the "ii" blood group a novel GCNT2 mutation was found in the cataract patients. PMID: 21541272
8. The I carbohydrate antigen interacts simultaneously with the entire hydrophobic patch in framework region 1 and with the outside surface of Ig heavy chain complementarity-determining region 3, leaving most of the site available for binding other antigens. PMID: 12244172
9. A nonsense mutation in the GCNT2 gene isoforms is associated with autosomal recessive congenital cataract in four distantly related Arab families from Israel. PMID: 15161861
10. role of C/EBPalpha in the induction of the IGnTC gene as well as in I antigen expression PMID: 17855628

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HGNC: 4204

OMIM: 110800

KEGG: hsa:2651

STRING: 9606.ENSP00000265012

UniGene: Hs.519884