GINS4 Antibody

Code CSB-PA871563LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA871563LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA871563LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GINS4 Polyclonal antibody
Uniprot No.
Target Names
GINS4
Alternative Names
DNA replication complex GINS protein SLD5 antibody; GINS complex subunit 4 (Sld5 homolog) antibody; GINS complex subunit 4 antibody; GINS4 antibody; SLD5 antibody; SLD5 homolog antibody; SLD5 S cerevisiae homolog of antibody; SLD5_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DNA replication complex GINS protein SLD5 protein (2-223AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GINS4 Antibody (Product code: CSB-PA871563LA01HU) is Non-conjugated. For GINS4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA871563LB01HU GINS4 Antibody, HRP conjugated ELISA
FITC CSB-PA871563LC01HU GINS4 Antibody, FITC conjugated
Biotin CSB-PA871563LD01HU GINS4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.
Gene References into Functions
  1. Knockdown of SLD5 using small interfering RNA resulted in reduction of cell growth both in vitro and an in vivo xenograft model. Moreover, we found that high levels of SLD5 in bladder cancer cells result from downregulation of microRNA (miR)-370 that otherwise suppresses its expression. PMID: 27499248
  2. Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase. PMID: 27592030
  3. The C-terminal domains of the Sld5 and Psf1 subunits are connected by linker regions to the core complex, and the C-terminal domain of Sld5 is important for core complex assembly. PMID: 17417653
Subcellular Location
Nucleus. Chromosome. Cytoplasm.
Protein Families
GINS4/SLD5 family
Database Links

HGNC: 28226

OMIM: 610611

KEGG: hsa:84296

STRING: 9606.ENSP00000276533

UniGene: Hs.656996

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