GPM6B Antibody

Code CSB-PA614417LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA614417LA01HU at dilution of 1:100
  • Immunofluorescent analysis of HepG2 cells using CSB-PA614417LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GPM6B Polyclonal antibody
Uniprot No.
Target Names
GPM6B
Alternative Names
GPM6B; M6B; Neuronal membrane glycoprotein M6-b; M6b
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Neuronal membrane glycoprotein M6-b protein (1-64AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GPM6B Antibody (Product code: CSB-PA614417LA01HU) is Non-conjugated. For GPM6B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA614417LB01HU GPM6B Antibody, HRP conjugated ELISA
FITC CSB-PA614417LC01HU GPM6B Antibody, FITC conjugated
Biotin CSB-PA614417LD01HU GPM6B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
Gene References into Functions
  1. Increase in the expression levels of mRNA and protein for the Gpm6B is associated with various types of gynaecological malignancy. PMID: 25113253
  2. Circulating levels of DR6 and Gpm6B correlate with breast cancer tumor grade. PMID: 24696529
  3. Data show the Differences in high resolution melting analysis in promoters of tumor markers neuronal membrane glycoprotein M6-B, melanoma antigen family A12 and immunoglobulin superfamily Fc receptor indicated invasiveness of hepatocellular carcinoma. PMID: 23950870
  4. Microarray expression analysis of GPM6B-depleted osteogenic human mesenchymal stem cells revealed significant changes in genes involved in cytoskeleton organization and biogenesis. PMID: 21638316
  5. it is unlikely that mutations in M6B have a role in Pelizaeus-Merzbacher-like syndrome, as examined in eight patients PMID: 15214007
  6. Data suggest that M6B regulates serotonin uptake by affecting cellular trafficking of the serotonin transporter. PMID: 18581270

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Myelin proteolipid protein family
Tissue Specificity
Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.
Database Links

HGNC: 4461

OMIM: 300051

KEGG: hsa:2824

UniGene: Hs.495710

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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