GZMH Antibody

1. Granzyme H did directly process DFF45, potentially leading to DNA damage. PMID: 23352961
2. Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition. PMID: 23269243
3. An unusual RKR motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites. PMID: 22156497
4. GzmH suppresses viral replication through association with the hepatitis B virus x protein. PMID: 22156339
5. Granzyme C rapidly induces target cell death by attacking nuclear and mitochondrial targets and that these targets are distinct from those used by granzyme B to cause classical apoptosis. PMID: 12515723
6. granzyme H complements the pro-apoptotic function of granzyme B in human NK cells PMID: 15069086
7. Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. PMID: 17363894
8. Expression levels of GzmH in naive natural killer cells and its killing ability support the role of the protease in triggering an alternative cell-death pathway in innate immunity. PMID: 17409270
9. GzmH may play an essential role in caspase-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB in human NK cells. PMID: 17765974
10. Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B. PMID: 17766182
11. Cleavage of La protein by granzyme H generates a COOH-terminal truncated form of La protein that loses nuclear localization and decreases hepatitis C virus-internal ribosome entry site-mediated translational activity. PMID: 19039329

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HGNC: 4710

OMIM: 116831

KEGG: hsa:2999

STRING: 9606.ENSP00000216338

UniGene: Hs.348264