ISX Antibody

Datasheet

Code	CSB-PA011854LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA011854LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human glioma using CSB-PA011854LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ISX Polyclonal antibody

Uniprot No.

Q2M1V0

Target Names

ISX

Alternative Names

DKFZp781N2395 antibody; Intestine-specific homeobox antibody; Isx antibody; ISX_HUMAN antibody; MGC138417 antibody; OTTHUMP00000028558 antibody; Pancreas intestine homeodomain transcription factor antibody; Pix 1 antibody; RAX like homeobox antibody; RAX-like homeobox antibody; RAXLX antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Intestine-specific homeobox protein (1-245AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ISX Antibody (Product code: CSB-PA011854LA01HU) is Non-conjugated. For ISX Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA011854LB01HU	ISX Antibody, HRP conjugated	ELISA
FITC	CSB-PA011854LC01HU	ISX Antibody, FITC conjugated
Biotin	CSB-PA011854LD01HU	ISX Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.

Gene References into Functions

our results indicate that E2F1 is an important downstream gene of ISX in hepatoma progression. PMID: 27175585
Results show that ISX expression mediated AHR-induced tumorigenesis in hepatocellular carcinoma. PMID: 28398627
Overall, our results identified a feed-forward mechanism of immune suppression in hepatocellular carcinoma organized by ISX, which involves kynurenine-AHR signaling and PD-L1, offering insights into immune escape by hepatocellular carcinoma PMID: 28625979
ISX expression induced by H. pylori infection may lead to intestinal metaplasia and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis. PMID: 26872890
Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX PMID: 23393141
our results highlight ISX as an important regulator in hepatoma progression with significant potential as a prognostic and therapeutic target in HCCs. PMID: 23221382

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Subcellular Location

Nucleus.

Database Links

HGNC: 28084

OMIM: 612019

KEGG: hsa:91464

STRING: 9606.ENSP00000311492

UniGene: Hs.567637

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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