KCTD6 Antibody

Code CSB-PA822756LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA822756LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA822756LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KCTD6 Polyclonal antibody
Uniprot No.
Target Names
KCTD6
Alternative Names
BTB/POZ domain-containing protein KCTD6 antibody; KCASH3 antibody; kctd6 antibody; KCTD6_HUMAN antibody; MGC27385 antibody; potassium channel tetramerization domain containing 6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The KCTD6 Antibody (Product code: CSB-PA822756LA01HU) is Non-conjugated. For KCTD6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA822756LB01HU KCTD6 Antibody, HRP conjugated ELISA
FITC CSB-PA822756LC01HU KCTD6 Antibody, FITC conjugated
Biotin CSB-PA822756LD01HU KCTD6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
Gene References into Functions
  1. A biophysical characterization of the POZ/BTB of KCTD6, is reported. PMID: 24307990
  2. Rescuing KCASHs expression reduces the Hedgehog-dependent medulloblastoma growth, suggesting that loss of members of this novel family of native HDAC inhibitors is crucial in sustaining Hh pathway-mediated tumorigenesis. PMID: 21472142
Subcellular Location
Cytoplasm, myofibril, sarcomere, M line.
Tissue Specificity
Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
Database Links

HGNC: 22235

KEGG: hsa:200845

STRING: 9606.ENSP00000347188

UniGene: Hs.13982

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