Function
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression.
Gene References into Functions
- GSK3beta-SKAP-Kif2b signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. PMID: 27982129
- Data indicate that Cep170 association with the C-terminus of Kif2b enhances localization of Kif2b to the spindle. PMID: 23087211
- Data show that Polo-like kinase 1 (Plk1) regulates both the localization and activity of kinesin-13 protein Kif2b during mitosis to promote the correction of k-MT attachment errors to ensure mitotic fidelity. PMID: 22535524
- Data show that CLASP1-astrin-Kif2b complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments. PMID: 20852589
- when microtubules are absent, the neck linker exists in equilibrium between two structural states; microtubule binding may activate the nucleotide-sensing mechanism of kinesin PMID: 12368902
- kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing, may be regulated by JIP1 PMID: 12893827
- These data demonstrate that Kif2b function is required for spindle assembly and chromosome movement and that the microtubule depolymerase activities of Kif2a, Kif2b, and MCAK fulfill distinct functions during mitosis in human cells. PMID: 17538014
- Here we show that two microtubule-depolymerizing kinesins, Kif2b and MCAK, stimulate kinetochore-microtubule dynamics during distinct phases of mitosis to correct mal-orientations. PMID: 19060894
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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, MCAK/KIF2 subfamily
Tissue Specificity
Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level).
