Product Details

Uniprot No.

Target Names

LPCAT1

Alternative Names

1 acylglycerophosphocholine O acyltransferase antibody; 1 alkylglycerophosphocholine O acetyltransferase antibody; 1-acylglycerophosphocholine O-acyltransferase antibody; 1-alkylglycerophosphocholine O-acetyltransferase antibody; Acetyl CoA:lyso PAF acetyltransferase antibody; Acetyl CoA:lyso platelet activating factor acetyltransferase antibody; Acetyl-CoA:lyso-PAF acetyltransferase antibody; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase antibody; Acyl CoA:lysophosphatidylcholine acyltransferase 1 antibody; Acyltransferase like 2 antibody; Acyltransferase-like 2 antibody; AGPAT10 antibody; AGPAT9 antibody; AYTL1 antibody; AYTL2 antibody; FLJ12443 antibody; FLJ41609 antibody; LPC acyltransferase 1 antibody; LPC acyltransferase antibody; lpcat antibody; LPCAT-1 antibody; LPCAT1 antibody; Lyso PAF acetyltransferase antibody; Lyso-PAF acetyltransferase antibody; LysoPAFAT antibody; LysoPC acyltransferase 1 antibody; Lysophosphatidylcholine acyltransferase 1 antibody; PCAT1_HUMAN antibody; PFAAP3 antibody; Phosphonoformate immuno associated protein 3 antibody; Phosphonoformate immuno-associated protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human LPCAT1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Exhibits acyltransferase activity. Exhibits acetyltransferase activity. Activity is calcium-independent. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size.

Gene References into Functions

fetal LPCAT1 mRNA present in maternal blood in quantity that correlates with lamellar body count PMID: 28926341
The overexpression of LPCAT1 promotes the development and progression of ccRCC, likely through the conversion of LPC to PC. PMID: 28494778
We found a direct correlation between LPCAT1 mRNA copies and the amniotic fluid lamellar body count. This finding corroborates an association between LPCAT1 and surfactant phospholipid biosynthesis. PMID: 25968427
Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations are associated with Gastric Cancer PMID: 25752890
No disease causing mutations in the LPCAT1 gene were identified, indicating that LPCAT1 either does not confer a genetic predisposition to retinitis pigmentosa, or incidence of mutations in LPCAT1 is particularly rare in patients with retinitis pigmentosa. PMID: 26260533
Down-regulation of LPCAT1 resulted in a decreased intercellular platelet-activating factor concentration and PAFR expression. PMID: 25803864
LPCAT1 is an independent predictor of early tumor recurrence of breast carcinoma and represents a novel prognostic biomarker that reflects underlying biological alterations PMID: 25683484
LPCAT1, a gene involved in the remodeling of phospholipids, was nominally associated with incident SCA risk. PMID: 24418166
The prognostic impact of LPCAT1 expression was independent of histological and clinical parameters. It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision-making. PMID: 23941784
effect of LPCAT1 overexpression or knockdown on cell proliferation, migration, and invasion in hepatocellular carcinoma cell lines PMID: 23567080
LPCAT1 correlates with the progression of prostate cancer. PMID: 22101258
full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing PMID: 20407208
hLPCAT1 is the biosynthetic enzyme of pulmonary surfactant phospholipids. PMID: 19383981
Aytl2 gene is the phosphatidylcholine reacylating enzyme in RBCs; this represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein PMID: 18156367
LPCAT1 may contribute to total choline metabolite accumulation via phosphatidylcholine remodeling, thereby altering the CRC lipid profile, a characteristic of malignancy. PMID: 18974965

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet.

Protein Families

1-acyl-sn-glycerol-3-phosphate acyltransferase family

Tissue Specificity

Erythrocytes.

Database Links

HGNC: 25718

OMIM: 610472

KEGG: hsa:79888

STRING: 9606.ENSP00000283415

UniGene: Hs.368853