LPXN Antibody

1. LPXN may facilitate bladder cancer progression by upregulating the expression of S100P via PI3K/AKT pathway. These results provide a novel insight into the role of LPXN in tumorigenesis and progression of bladder cancer and potential therapeutic target of bladder cancer. PMID: 29975926
2. this is the first demonstration of a role for the leupaxin in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin transcription activity. PMID: 26361959
3. The full-length leupaxin binds to the Pyk2-focal adhesion targeting domain. PMID: 26866573
4. Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein CaD and regulates CaD phosphorylation by recruiting ERK to highly dynamic structures within PCa cells. PMID: 26079947
5. Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions. PMID: 25955236
6. first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors PMID: 20543562
7. leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling. PMID: 19917054
8. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex PMID: 12674328
9. Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP. PMID: 15786712
10. These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. PMID: 17329398
11. Leupaxin plays an inhibitory role in BCR signaling and B cell function. PMID: 17640867
12. leupaxin could serve as a potential progression marker for a subset of PCa and may represent a novel coactivator of the androgen receptor PMID: 18451096
13. Leupaxin is enriched in vascular smooth nuscle. It undergoes cytoplasmic/nuclear shuttling & functions as an serum response factor cofactor. It associates with CArG-containing regions. Its ectopic expression induces smooth muscle marker gene expression. PMID: 18497331
14. LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation. PMID: 19760607

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HGNC: 14061

OMIM: 605390

KEGG: hsa:9404

STRING: 9606.ENSP00000431284

UniGene: Hs.125474