LRRFIP1 Antibody

Datasheet

Code	CSB-PA013175HA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA013175HA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA013175HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA013175HA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LRRFIP1 Polyclonal antibody

Uniprot No.

Q32MZ4

Target Names

LRRFIP1

Alternative Names

FLAP 1 antibody; FLAP1 antibody; FLIIAP 1 antibody; FLIIAP1 antibody; GC binding factor 2 antibody; GC-binding factor 2 antibody; GCF 2 antibody; GCF2 antibody; HUFI 1 antibody; HUFI1 antibody; Leucine rich repeat (in FLII) interacting protein 1 antibody; Leucine rich repeat flightless interacting protein 1 antibody; Leucine-rich repeat flightless-interacting protein 1 antibody; LRR FLII interacting protein 1 antibody; LRR FLII-interacting protein 1 antibody; LRRF1_HUMAN antibody; LRRFIP 1 antibody; Lrrfip1 antibody; MGC10947 antibody; MGC119738 antibody; MGC119739 antibody; NEDD8 conjugating enzyme antibody; TAR RNA interacting protein antibody; TAR RNA-interacting protein antibody; Transcription factor 9 like antibody; TRIP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Leucine-rich repeat flightless-interacting protein 1 protein (1-315AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LRRFIP1 Antibody (Product code: CSB-PA013175HA01HU) is Non-conjugated. For LRRFIP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA013175HB01HU	LRRFIP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013175HC01HU	LRRFIP1 Antibody, FITC conjugated
Biotin	CSB-PA013175HD01HU	LRRFIP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Gene References into Functions

Results show that LRRFIP-1 is mainly produced by keratinocytes in the unwounded skin but is upregulated in both keratinocytes and fibroblasts in response to wounding, suggesting a role in the wound repair process. PMID: 29996558
Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/beta-catenin signaling pathway. PMID: 26047573
High GCF2 expression is associated with hepatoma. PMID: 24761896
Higher baseline LRRFIP1 expression in human glioblastoma multiforme tissue (n=60) is associated with better prognosis upon later treatment with teniposide. PMID: 24690174
Data indicate that LRRFIP1 knockdown increased resting TNF mRNA level altered the ncRNA abundance at the LRRFIP1 binding region. PMID: 24567534
Eight SNPs (rs7575941, rs3769053, rs11689421, rs3820808, rs11680012, rs3806505, rs6739130, and rs11686141) showed evidence of association with at least two adiposity phenotypes and plasma levels of one marker of inflammation. PMID: 23505185
The FLI-interacting domain of LRRFIP1 forms a classic parallel, homodimeric coiled coil with 10 heptad repeats and 22 helical turns. PMID: 23099021
GCF2/LRRFIP1 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion. PMID: 22750095
LRRFIP1 is phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures. PMID: 21102652
An association study of 6 of the 63 genes in 4235 cases and 6379 controls showed a putative association with myocardial infarction for COMMD7 (COMM domain-containing protein 7) and a major deviation from the null hypo thesis for LRRFIP1. PMID: 20833976
GCF2/LRRFIP1 appears to act as a repressor and occupies the -308 site in cells that do not make TNF-alpha. PMID: 16199883
Immediately following lipopolysaccharide stimulation, both LRRFIP2 and Flap-1/LRRFIP1 compete with Fliih for interacting with MyD88 to activate the signaling. PMID: 19265123

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

LRRFIP family

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 6702

OMIM: 603256

KEGG: hsa:9208

STRING: 9606.ENSP00000375857

UniGene: Hs.471779

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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