LRTOMT Antibody

Datasheet

Code	CSB-PA02667A0Rb
Size	US$166
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Image	Immunofluorescent analysis of HepG2 cells using CSB-PA02667A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LRTOMT Polyclonal antibody

Uniprot No.

Q8WZ04

Target Names

LRTOMT

Alternative Names

TOMT; COMT2; LRTOMT; PP7517; Transmembrane O-methyltransferase; Catechol O-methyltransferase 2; Protein LRTOMT2

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transmembrane O-methyltransferase protein (31-264AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LRTOMT Antibody (Product code: CSB-PA02667A0Rb) is Non-conjugated. For LRTOMT Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA02667B0Rb	LRTOMT Antibody, HRP conjugated	ELISA
FITC	CSB-PA02667C0Rb	LRTOMT Antibody, FITC conjugated
Biotin	CSB-PA02667D0Rb	LRTOMT Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity.

Gene References into Functions

Results indicate that mutations in the LRT)MT gene lead to alterations in the LRTOMT2 protein and might be involved in progressive sensorineural hearing loss. PMID: 25788562
LRTOMT gene is the second cause of congenital hearing impairment in Moroccan patients. PMID: 23053991
A 1 bp deletion in the dual reading frame deafness gene LRTOMT causes a frameshift from the first into the second reading frame. PMID: 21739586
A genome wide linkage analysis of nonsyndromic deafness segregating in a consanguineous Pakistani family (PKDF537) was used to identify DFNB63, a new locus for congenital profound sensorineural hearing loss. PMID: 17066295
Haplotype analysis defined a 5.55 Mb critical region between microsatellite markers D11S4136 and D11S4081. PMID: 17166180
The locus associated with ARNSHI PMID: 17211611
nonsense mutation in the human ortholog of the murine Comt2 gene that causes nonsyndromic deafness PMID: 18794526
Mutations of LRTOMT are associated with profound nonsyndromic hearing loss at the DFNB63 locus on human chromosome 11q13.3-q13.4. PMID: 18953341

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Involvement in disease

Deafness, autosomal recessive, 63 (DFNB63)

Subcellular Location

[Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 2]: Cytoplasm. Endoplasmic reticulum.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family

Database Links

HGNC: 25033

OMIM: 611451

KEGG: hsa:220074

STRING: 9606.ENSP00000305742

UniGene: Hs.317243

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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