MESP2 Antibody

Code CSB-PA613150ESR1HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MESP2 Polyclonal antibody
Uniprot No.
Target Names
MESP2
Alternative Names
Basic helix loop helix protein MESP 2 antibody; Basic helix loop helix protein MESP2 antibody; BHLH protein MesP2 antibody; bHLHc6 antibody; Class C basic helix-loop-helix protein 6 antibody; Hypothetical class II basic helix loop helix protein MESP 2 antibody; Hypothetical class II basic helix loop helix protein MESP2 antibody; Mesoderm posterior 2 antibody; mesoderm posterior 2 homolog (mouse) antibody; Mesoderm posterior 2 homolog antibody; Mesoderm posterior protein 2 antibody; Mesp 2 antibody; MESP2 antibody; MESP2_HUMAN antibody; SCDO 2 antibody; SCDO2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Mesoderm posterior protein 2 protein (218-397AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
Gene References into Functions
  1. Mutated MESP2 causes spondylocostal dysostosis PMID: 15122512
  2. Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo. PMID: 16996494
  3. findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome PMID: 18485326
Involvement in disease
Spondylocostal dysostosis 2, autosomal recessive (SCDO2)
Subcellular Location
Nucleus.
Database Links

HGNC: 29659

OMIM: 605195

KEGG: hsa:145873

STRING: 9606.ENSP00000342392

UniGene: Hs.37311

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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