MT1G Antibody

Datasheet

Code	CSB-PA17384A0Rb
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA17384A0Rb at dilution of 1: 100
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MT1G Polyclonal antibody

Uniprot No.

P13640

Target Names

MT1G

Alternative Names

Metallothionein-1G antibody; Metallothionein-1K antibody; Metallothionein-IG antibody; MT-1G antibody; MT-1K antibody; MT-IG antibody; MT1G antibody; MT1G_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Metallothionein-1G protein (1-59AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MT1G Antibody (Product code: CSB-PA17384A0Rb) is Non-conjugated. For MT1G Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA17384B0Rb	MT1G Antibody, HRP conjugated	ELISA
FITC	CSB-PA17384C0Rb	MT1G Antibody, FITC conjugated
Biotin	CSB-PA17384D0Rb	MT1G Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

CUSABIO produced the MT1G polyclonal antibody (CSB-PA17384A0Rb) by immunizing rabbits with the synthetic peptide corresponding to the amino acids 1-59 of the recombinant human MT1G protein. The anti-MT1G antibody was purified from rabbit antiserum by protein G affinity chromatography. Its purity reaches up to 95%. It occurs as an unconjugated IgG.

This MT1G polyclonal antibody only reacts with human MT1G, which suppresses growth, migration, and invasion but induces cell cycle arrest and apoptosis in thyroid cancer cells. This MT1G antibody is suitable for the detection of MT1G protein in ELISA and IHC applications.

Citations

MT1G, an emerging ferroptosis‐related gene: A novel prognostic biomarker and indicator of immunotherapy sensitivity in prostate cancer B Cheng,Environmental toxicology,2023

Customer Reviews and Q&A

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Target Background

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene References into Functions

These findings indicate that MT1 constitute a biomarker adapted for exploring the impact of sorafenib on the redox metabolism of cancer cells. PMID: 27184800
A new tumor-suppressor activity of MT1G in colorectal cancer cells.MT1G role in cell differentiation. PMID: 28393194
PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation PMID: 25072246
MT1G was down-regulated in renal cell carcinogenesis. PMID: 24662736
MT1M and MT1G promoter methylation may be used as serum biomarkers for noninvasive detection of hepatocellular carcinoma. PMID: 24782625
Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy. PMID: 24634414
Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. PMID: 24098937
GPR56, MT1G, and RASSF1 might be the potential methylation markers associated with acquired multidrug resistance of lung adenocarcinoma. PMID: 23902976
Results describe MT1G promoter hypermethylation in hepatoblastoma and demonstrate that aberrant methylation is a frequent event in this malignancy. PMID: 20032811
Loss of metallothionein 1G function due to hypermethylation of its promoter leads to athogenesis of papillary thyroid carcinoma PMID: 12640681
Induction of the hMT1G promoter by VEGF and heavy metals occurs through the utilization of different transcription factors. PMID: 15735762
Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity. PMID: 15747776
MT1G is hypermethylated in renal cell carcinoma. PMID: 18639284
Using a panel of four genes (AHRR, p16INK4a, MT1G, and CLDN3) resulted in sensitivity and specificity of 50% and 68%, respectively and may have utility for early detection of esophageal squamous dysplasia and early ESCC. PMID: 19137073
Promoter methylation and differential gene expression of five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated by sequencing of bisulfite-modified DNA and real-time reverse transcriptase PCR, respectively. PMID: 19491193
p16INK4A, DAPK1, PTEN and MT1G genes were not frequently methylated in the stage I non-small cell lung cancer in China. PMID: 19506903
MT1G acts as a tumor suppressor gene in hepatocellular carcinoma PMID: 19639168

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Protein Families

Metallothionein superfamily, Type 1 family

Database Links

HGNC: 7399

OMIM: 156353

KEGG: hsa:4495

STRING: 9606.ENSP00000391397

UniGene: Hs.433391

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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