MYO5B Antibody

1. Data suggest that single-headed myosin-5B is intermediate-duty ratio motor with kinetic ATPase cycle, rate-limited by phosphate release; in transition to high-duty ratio motor, second head generates strain/gating in myosin-5B dimer that alter kinetic signature by slowing actin-activated ADP release to become rate-limiting; myosin-5B mutations cause microvillus inclusion disease and impact myosin motor function. PMID: 28882893
2. findings show for the first time that MYO5B deficiency may lead to cholestasis without microvillus inclusion disease PMID: 27532546
3. MYO5B deficiency may underlie 20% of previously undiagnosed low-gamma-glutamyltransferase cholestasis. MYO5B deficiency appears to impair targeting of bile salt export pump to the canalicular membrane with hampered bile acid excretion, resulting in a spectrum of cholestasis without diarrhea. PMID: 28027573
4. Myosin Vb regulates the Cu(+)-stimulated delivery of ATP7B to the apical domain of polarized hepatic cells. PMID: 26823605
5. GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3. PMID: 26553929
6. Report changes in polarized signaling resulting from Myo5b loss-of-function mutations in microvillus inclusion disease. PMID: 25258405
7. Part of the machinery for ezrin activation depends on recycling endosomes controlled by myosin Vb and Rab11a. PMID: 24413175
8. MYO5B-rs555879 is a risk factor for dyslexia in a German cohort. PMID: 24373531
9. Microvilli establishment required interaction between RAB8A and MYO5B, while loss of the interaction between RAB11A and MYO5B induced microvillus inclusions. PMID: 24892806
10. Cholestasis in microvillus inclusion disease results from impairment of the MYO5B/RAB11A apical recycling endosome pathway in hepatocytes, altered targeting of bile export pump to the canalicular membrane, and increased ileal bile acid absorption. PMID: 24375397
11. Loss of MYO5b causes loss of apical microvilli, formation of inclusion bodies an protein trafficking defects in CaCo2 cells. PMID: 24138727
12. The data of this study supported that the MYO5B gene might be associated with schizophrenia in the Chinese Han population. PMID: 23561489
13. MYO5B is epigenetically silenced in gastric cancer cells by DNA methylation and histone modification. Inactivation of MYO5B in gastric cancer cells expressing MYO5B inhibits HGF-stimulated MET degradation with sustained c-MET levels and signaling. PMID: 23456500
14. Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane PMID: 22420646
15. MYO5B mutations have divergent effects on the apical membrane system in kidney and intestinal epithelial cells. PMID: 22441677
16. Inactivation of MYO5B by siRNA against MYO5B can promote cell proliferation, invasion and motility.The expression of MYO5B was downregulated in gastric cancer and inactivation of MYO5B may contribute to tumorigenesis. PMID: 22134786
17. Our functional analysis indicates that MYO5B mutations can be correlated with an aberrant subcellular distribution of the myosin Vb protein, and apical recycling endosomes... PMID: 21206382
18. Molecular analysis of the MYO5B gene is helpful in genetic counseling and prenatal diagnosis of recurrent microvillus inclusion disease in subsequent pregnancies. PMID: 21199752
19. In polarized epithelial cyst cultures, Myo5B was required for apical membrane trafficking and de novo lumen formation, dependent on association with both Rab8a and Rab11a. PMID: 21282656
20. 15 novel nonsense and missense mutations in MYO5B in 11 unrelated microvillus inclusion disease patients;MYO5B mutations are a major cause of disease PMID: 20186687
21. Myosin Vb was present in nucleoli where it co-localises with RNA polymerase I, and newly synthesised ribosomal RNA. Vb was also found to physically associate with RNA polymerase I and actin in co-immunoprecipitation experiments. PMID: 19610025
22. Data suggest that polarization of hepatocytes requires recruitment of rab11a and myosin Vb to intracellular membranes that contain apical ABC transporters and transcytotic markers. PMID: 16214890
23. myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells PMID: 17462998
24. MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity. PMID: 18724368
25. A shared homozygous mutation in MYO5B in seven affected Navajos with the expected heterozygosity in five parents, was identified. PMID: 19006234
26. Genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18317468
27. Dominant negative approach suggests MYO5B plays a role in plasma membrane recycling (through early endosomes). PMID: 11408590

Show More

Hide All

HGNC: 7603

OMIM: 251850

KEGG: hsa:4645

STRING: 9606.ENSP00000285039

UniGene: Hs.720076