NAE1 Antibody

Code CSB-PA195686
Size US$166
Order now
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA195686(NAE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA195686(NAE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
NAE1
Alternative Names
59 kDa antibody; A 116A10.1 antibody; Amyloid beta precursor protein binding protein 1 59kD antibody; Amyloid beta precursor protein binding protein 1 59kDa antibody; Amyloid beta precursor protein binding protein 1 antibody; Amyloid beta precursor protein binding protein 1, 59 kDa antibody; Amyloid beta precursor protein-binding protein 1 antibody; Amyloid protein binding protein 1 antibody; Amyloid protein-binding protein 1 antibody; APP BP1 antibody; APP-BP1 antibody; APPBP 1 antibody; APPBP1 antibody; HPP 1 antibody; HPP1 antibody; NAE 1 antibody; NAE1 antibody; NEDD8 activating enzyme E1 regulatory subunit antibody; NEDD8 activating enzyme E1 subunit 1 antibody; NEDD8 activating enzyme E1 subunit antibody; NEDD8-activating enzyme E1 regulatory subunit antibody; Proto oncogene protein 1 antibody; Proto-oncogene protein 1 antibody; Protooncogene protein 1 antibody; ula 1 antibody; ULA1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human NAE1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:15-1:50
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Gene References into Functions
  1. Here we report that high expression of neddylation components, NEDD8 and NAE1, are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence PMID: 28535453
  2. E1 (NAE1 and UBA3) and E2 (UBC12) enzymes, as well as global NEDD8 conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma PMID: 25229838
  3. analysis of a metal-based inhibitor of NEDD8-activating enzyme PMID: 23185368
  4. our results suggest that APP-BP1 modulates neuronal differentiation by altering gene expression profiles in fetal neural stem cells PMID: 22182960
  5. APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells PMID: 21151996
  6. APP-BP1 displayed decreased expression levels in HPV-positive head and neck squamous cell carcinoma PMID: 19795456
  7. structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8 PMID: 12646924
  8. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. PMID: 12740388
  9. Data report the structure of the quaternary complex between human APPBP1-UBA3, a heterodimeric E1, its ubl NEDD8, and ATP. PMID: 14690597
  10. APP-BP1 is degraded by ubiquitin-dependent proteolysis. PMID: 18627766

Show More

Hide All

Subcellular Location
Cell membrane. Note=Colocalizes with APP in lipid rafts.
Protein Families
Ubiquitin-activating E1 family, ULA1 subfamily
Tissue Specificity
Ubiquitous in fetal tissues. Expressed throughout the adult brain.
Database Links

HGNC: 621

OMIM: 603385

KEGG: hsa:8883

STRING: 9606.ENSP00000290810

UniGene: Hs.460978

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*