NAE1 Antibody

Code CSB-PA015411GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
59 kDa antibody; A 116A10.1 antibody; Amyloid beta precursor protein binding protein 1 59kD antibody; Amyloid beta precursor protein binding protein 1 59kDa antibody; Amyloid beta precursor protein binding protein 1 antibody; Amyloid beta precursor protein binding protein 1, 59 kDa antibody; Amyloid beta precursor protein-binding protein 1 antibody; Amyloid protein binding protein 1 antibody; Amyloid protein-binding protein 1 antibody; APP BP1 antibody; APP-BP1 antibody; APPBP 1 antibody; APPBP1 antibody; HPP 1 antibody; HPP1 antibody; NAE 1 antibody; NAE1 antibody; NEDD8 activating enzyme E1 regulatory subunit antibody; NEDD8 activating enzyme E1 subunit 1 antibody; NEDD8 activating enzyme E1 subunit antibody; NEDD8-activating enzyme E1 regulatory subunit antibody; Proto oncogene protein 1 antibody; Proto-oncogene protein 1 antibody; Protooncogene protein 1 antibody; ula 1 antibody; ULA1_HUMAN antibody
Raised in
Species Reactivity
Human NAE1
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Gene References into Functions
  1. Here we report that high expression of neddylation components, NEDD8 and NAE1, are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence PMID: 28535453
  2. E1 (NAE1 and UBA3) and E2 (UBC12) enzymes, as well as global NEDD8 conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma PMID: 25229838
  3. analysis of a metal-based inhibitor of NEDD8-activating enzyme PMID: 23185368
  4. our results suggest that APP-BP1 modulates neuronal differentiation by altering gene expression profiles in fetal neural stem cells PMID: 22182960
  5. APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells PMID: 21151996
  6. APP-BP1 displayed decreased expression levels in HPV-positive head and neck squamous cell carcinoma PMID: 19795456
  7. structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8 PMID: 12646924
  8. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. PMID: 12740388
  9. Data report the structure of the quaternary complex between human APPBP1-UBA3, a heterodimeric E1, its ubl NEDD8, and ATP. PMID: 14690597
  10. APP-BP1 is degraded by ubiquitin-dependent proteolysis. PMID: 18627766

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Subcellular Location
Cell membrane. Note=Colocalizes with APP in lipid rafts.
Protein Families
Ubiquitin-activating E1 family, ULA1 subfamily
Tissue Specificity
Ubiquitous in fetal tissues. Expressed throughout the adult brain.
Database Links

HGNC: 621

OMIM: 603385

KEGG: hsa:8883

STRING: 9606.ENSP00000290810

UniGene: Hs.460978

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