NEU2 Antibody

1. Synchrotron radiation reflectometry was used to access the transverse structure of model membranes under the action of the human sialidase NEU2, down to the Angstrom length scale PMID: 28087363
2. cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein PMID: 26193330
3. Circular dichroism (CD) spectra at variable temperatures have been recorded for human cytosolic sialidase NEU2 in buffered water solutions and in the presence of divalent cations. PMID: 25033330
4. Q136K is a novel mutation in an expressed NEU2 protein that was discovered during crystallographic analysis. PMID: 23908028
5. the present study demonstrated NEU2 expression to be detectable but very low in many human tissues and cells, and suggested possible functional roles in PC-3 prostate cancer cells. PMID: 23068092
6. NEU2 appears to be activated when lysine 45 and glutamine 112 are mutated to alanine. PMID: 22228546
7. HsNEU2 differentially recognizes the type of sialosyl linkage, the aglycone part of the substrate, and the supramolecular organization (monomer/micelle/vesicle) of gangliosides PMID: 14613940
8. the first high resolution x-ray structures of sialidase, human Neu2 PMID: 15501818
9. propose that this Asian-enriched sialidase variation caused by the SNP, likely in homozygous form, may be associated with certain severe adverse reactions to oseltamivir PMID: 17426694
10. Neu2 loss of expression might exacerbate the defective myogenic differentiation of rhabdomyosarcoma cells. PMID: 19524683

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HGNC: 7759

OMIM: 605528

KEGG: hsa:4759

STRING: 9606.ENSP00000233840

UniGene: Hs.532681