NFIC Antibody

1. Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for the interaction of the (apolipoprotein E) APOE epsilon4 allele with NFIC SNP. PMID: 28183528
2. Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer PMID: 25879941
3. Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs. PMID: 24801901
4. Over-expression of NFIC increased cell proliferation, mineralization nodule formation and alkaline phosphatase activity in stem cells from the apical papilla. PMID: 25668322
5. transcription factor Nuclear Factor 1-C (NF1C) as a candidate to regulate AHR transcription in a polymorphism-dependent manner PMID: 23208493
6. These data suggest a critical role for calcineurin in NFI transcriptional regulation and in the determination of malignant glioma infiltrative properties. PMID: 23839947
7. the influence of i3T3 on the expression and DNA binding of NFI, another TF important for cell proliferation and cell cycle progression PMID: 22420942
8. novel role of NF1-C2 in tumor development and epithelial-to-mesenchymal transition in breast cancer; NF1-C2 is lost during tumor progression and virtully absent from lymph node metastases; FoxF1 was was found to be a direct repressed target of NF1-C2 PMID: 20145151
9. A specific region (-688 to -611 bp) was discovered in the IRS2 promoter essential for basal promoter activity and oxidative stress induced transcription depending on ERK activation and SP1 and NFI binding in human hepatocytes. PMID: 19755487
10. diminished NF-1C-dependent repression may be one mechanism underlying increased basal CYP17 promoter activity and altered gene expression in PCOS (polycystic ovary syndrome) theca cells. PMID: 14684846
11. The BAF complex & NF1/CTF might act as components of the RNAP II holoenzyme to participate in formation of transcriptional pre-initiation complex. PMID: 15999204
12. Data demonstrate that nuclear Jak2 regulates the amount of active NF1-C2 through tyrosine phosphorylation and proteasomal degradation. PMID: 16847321
13. the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1 PMID: 17186943
14. we suggest that bHLH factors recruit NFI to enhance skeletal muscle Na(+) channel expression. PMID: 17936922
15. All NFI isoforms were found to be expressed in human corneal epithelial cells grown on laminin. PMID: 18421093
16. These are the first studies to analyze the expression of NFI-C isoforms in dental versus nondental cells/tissues. PMID: 18765927
17. These results suggest that alpha5 gene expression is likely dictated by subtle alterations in the nuclear ratio of TFs that either repress (NFI) or activate (Sp1 and AP-1) alpha5 transcription in corneal epithelial cells. PMID: 18775869
18. These results imply a central role of NFI-C in the interplay of the two signaling pathways and in regulation of the progression of tissue regeneration. PMID: 19752192

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HGNC: 7786

OMIM: 600729

KEGG: hsa:4782

STRING: 9606.ENSP00000465655

UniGene: Hs.170131