NFIX Antibody

1. Microduplications encompassing NFIX cause intellectual disability, short stature and small head circumference. PMID: 29184170
2. Compared to noncancerous esophageal mucosa, miR-1290 expression was upregulated, while NFIX mRNA expression was downregulated in ESCC tissues. Data suggest that the dysregulation of miR-1290-NFIX axis may play crucial roles in esophageal carcinogenesis and progression. PMID: 28800311
3. A novel de novo pathogenic variant in the NFIX gene identified in a case of Marshall-Smith syndrome with precocious puberty and aortic root dilatation. PMID: 28442439
4. Plasma miR-1914* and -1915 interact with NFIX RNA. PMID: 26695693
5. Report novel mutations of NFIX gene causing Marshall-Smith syndrome or Sotos-like syndrome. PMID: 26200704
6. miR-1290 functions as a tumor oncogene in the progression of esophageal squamous cell carcinoma by targeting NFIX PMID: 26653554
7. NFIX analysis should be considered in patients presenting with overgrowth, macrocephaly and developmental delay including those in whom Sotos syndrome has been considered clinically but are negative for pathogenic NSD1 variants. PMID: 25118028
8. Deletions in the 3' part of the NFIX gene including a recurrent Alu-mediated deletion of exon 6 and 7 account for previously unexplained cases of Marshall-Smith syndrome. PMID: 24924640
9. missense mutations in NFIX were able to cause Sotos-like features. PMID: 22301465
10. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. PMID: 22422452
11. NFI-X3 and STAT3 control the migration of differentiating astrocytes as well as migration and invasion of glioma cells via regulating YKL-40 expression. PMID: 21953450
12. NFI-X3 activates GFAP expression, in part, by inducing alterations in the nucleosome architecture that lead to the increased recruitment of RNA polymerase II PMID: 21189253
13. These findings demonstrate that allelic NFIX mutations trigger distinct phenotypes, depending specifically on their impact on nonsense-mediated mRNA decay. PMID: 20673863
14. Nuclear factor IA may play a role in astrocytoma biology. PMID: 20150379
15. NFI-X cooperates with (activator protein 1)AP-1 by an unknown mechanism in astrocytes, which results in the expression of a subset of astrocyte-specific genes. PMID: 16565071
16. temporal and dose-dependent interference by an AP-1 family member, c-Jun, upon NF-1 proteins binding an NF-1 consensus site derived from JC virus promoter sequence PMID: 16928756
17. First report of structural alterations of the NFIA gene in hematopoietic diseases (polycythemia vera and chronic myelomonocytic leukemia, type 1). PMID: 18754024
18. an expression program of NFIs is executed during the differentiation of astrocytes, with NFI-X and -C controlling the expression of astrocytic markers at late stages of differentiation. PMID: 19418463

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HGNC: 7788

OMIM: 164005

KEGG: hsa:4784

STRING: 9606.ENSP00000380781

UniGene: Hs.257970