NKIRAS2 Antibody

Datasheet

Code	CSB-PA873696LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA873696LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NKIRAS2 Polyclonal antibody

Uniprot No.

Q9NYR9

Target Names

NKIRAS2

Alternative Names

DKFZP434N1526 antibody; I kappa B interacting Ras like protein 2 antibody; I-kappa-B-interacting Ras-like protein 2 antibody; Kappa B Ras protein 2 antibody; Kappa B-Ras protein 2 antibody; KappaB Ras2 antibody; KappaB-Ras2 antibody; KBRAS 2 antibody; KBRAS2 antibody; KBRS2_HUMAN antibody; MGC74742 antibody; NF kappa B inhibitor interacting Ras like protein 2 antibody; NF-kappa-B inhibitor-interacting Ras-like protein 2 antibody; NFKB inhibitor interacting Ras like 2 antibody; NFKB inhibitor interacting Ras like protein 2 antibody; NKIRAS 2 antibody; NKIRAS2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 2 protein (1-191AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NKIRAS2 Antibody (Product code: CSB-PA873696LA01HU) is Non-conjugated. For NKIRAS2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA873696LB01HU	NKIRAS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873696LC01HU	NKIRAS2 Antibody, FITC conjugated
Biotin	CSB-PA873696LD01HU	NKIRAS2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.

Gene References into Functions

GBM cells overexpressing TNFAIP3 and NKIRAS2 were refractory to miR-125b-induced apoptosis resistance as well as TMZ resistance, indicating that both genes are relevant targets of miR-125b. PMID: 24901050
KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. PMID: 20639196

Subcellular Location

Cytoplasm.

Protein Families

Small GTPase superfamily, Ras family, KappaB-Ras subfamily

Tissue Specificity

Widely expressed.

Database Links

HGNC: 17898

OMIM: 604497

KEGG: hsa:28511

STRING: 9606.ENSP00000303580

UniGene: Hs.632252

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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