NKIRAS2 Antibody

Code CSB-PA015834GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
NKIRAS2
Alternative Names
DKFZP434N1526 antibody; I kappa B interacting Ras like protein 2 antibody; I-kappa-B-interacting Ras-like protein 2 antibody; Kappa B Ras protein 2 antibody; Kappa B-Ras protein 2 antibody; KappaB Ras2 antibody; KappaB-Ras2 antibody; KBRAS 2 antibody; KBRAS2 antibody; KBRS2_HUMAN antibody; MGC74742 antibody; NF kappa B inhibitor interacting Ras like protein 2 antibody; NF-kappa-B inhibitor-interacting Ras-like protein 2 antibody; NFKB inhibitor interacting Ras like 2 antibody; NFKB inhibitor interacting Ras like protein 2 antibody; NKIRAS 2 antibody; NKIRAS2 antibody
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NKIRAS2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Gene References into Functions
  1. GBM cells overexpressing TNFAIP3 and NKIRAS2 were refractory to miR-125b-induced apoptosis resistance as well as TMZ resistance, indicating that both genes are relevant targets of miR-125b. PMID: 24901050
  2. KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. PMID: 20639196
Subcellular Location
Cytoplasm.
Protein Families
Small GTPase superfamily, Ras family, KappaB-Ras subfamily
Tissue Specificity
Widely expressed.
Database Links

HGNC: 17898

OMIM: 604497

KEGG: hsa:28511

STRING: 9606.ENSP00000303580

UniGene: Hs.632252

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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