NKX2-6 Antibody

Code CSB-PA003457
Size US$100
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  • Western Blot analysis of COLO205 cells using Nkx-2.6 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
NKX2-6
Alternative Names
NKX2-6 antibody; NKX2F antibody; Homeobox protein Nkx-2.6 antibody; Homeobox protein NK-2 homolog F antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human Nkx-2.6.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.
Gene References into Functions
  1. This study firstly links NKX2.6 loss-of-function mutation with increased susceptibility to isolated VSD. PMID: 25380965
  2. Data associated genetically defective NK2 homeobox 6 (NKX2-6) with enhanced susceptibility to atrial fibrillation (AF). PMID: 25319568
  3. Heterozygous mutations in Nkx2.6, p.V176M and p.K177X, were identified in 2 unrelated patients, one with tetralogy of Fallot and one with double outlet of right ventricle and ventricular septal defect. Increased vulnerability to TOF or DORV is discussed. PMID: 25195019
  4. NKX2-6 plays a role in human cardiogenesis. PMID: 24421281
  5. weakly activates transcription of a Cx40 promoter, may have role in heart development PMID: 15649947
  6. NKX2.5/NKX2.6 mutations are not a common cause of isolated type 1 truncus arteriosus in a small cohort of multiethnic cases. PMID: 18939937

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Involvement in disease
Conotruncal heart malformations (CTHM)
Subcellular Location
Nucleus.
Protein Families
NK-2 homeobox family
Database Links

HGNC: 32940

OMIM: 217095

KEGG: hsa:137814

STRING: 9606.ENSP00000320089

UniGene: Hs.532654

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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